ID   A0A0P4R162_9ACTN        Unreviewed;      1034 AA.
AC   A0A0P4R162;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Putative LuxR family transcriptional regulator {ECO:0000313|EMBL:GAO06564.1};
GN   ORFNames=TPA0598_01_09350 {ECO:0000313|EMBL:GAO06564.1};
OS   Streptomyces lydicamycinicus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1546107 {ECO:0000313|EMBL:GAO06564.1, ECO:0000313|Proteomes:UP000048965};
RN   [1] {ECO:0000313|Proteomes:UP000048965}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 110027 {ECO:0000313|Proteomes:UP000048965};
RA   Komaki H., Ichikawa N., Katano-Makiyama Y., Hosoyama A., Hashimoto M.,
RA   Uohara A., Kitahashi Y., Ohji S., Kimura A., Yamazoe A., Igarashi Y.,
RA   Fujita N.;
RT   "Whole genome shotgun sequence of Streptomyces sp. NBRC 110027.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:GAO06564.1, ECO:0000313|Proteomes:UP000048965}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 110027 {ECO:0000313|EMBL:GAO06564.1,
RC   ECO:0000313|Proteomes:UP000048965};
RX   PubMed=26380643; DOI=10.1186/s40793-015-0046-5;
RA   Komaki H., Ichikawa N., Hosoyama A., Fujita N., Igarashi Y.;
RT   "Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a
RT   producer of anti-MRSA antibiotic lydicamycins.";
RL   Stand. Genomic Sci. 10:58-58(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAO06564.1}.
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DR   EMBL; BBNO01000001; GAO06564.1; -; Genomic_DNA.
DR   RefSeq; WP_042149125.1; NZ_BBNO01000001.1.
DR   AlphaFoldDB; A0A0P4R162; -.
DR   OrthoDB; 5476461at2; -.
DR   Proteomes; UP000048965; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000048965}.
FT   DOMAIN          961..1026
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50043"
FT   REGION          937..964
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1034 AA;  111929 MW;  78678C88493CAB89 CRC64;
     MLSGVETRSV SPVFVGRAAE LAALGDALDR IAASGEPQAL LIGGEAGVGK TRLIEEFGES
     ARARGALVAL GGCIEIGSEG LPFAPFSAIL HTLNWHLRDE LAAAVAGQEG ELSRILPELG
     ETPGEAHDEE IGRARLFELT ARLLERLAAD RTLVLVIEDL HWADRSTREL LAYLLRALHD
     ANVLLVATYR SDDIHRRHPL RPFLAEIDRM RTVRRVELAR FNREEVRSQI AGINGSDPEE
     DTVDRVFKRS EGNAFFVEEL ARGLAEGALH GLSDPLRDLL LVRVEALPED AQRVVRTAAE
     GGSTVEHELL SAVCRMPEDD LIEALRAAVG SNILVPTQDG TGYRFRHALA REAVVDDLLP
     GERTRLNRRY AEALEAGPSL VRAEVCAARL ASYWYKAHDA AKALPAVLAA SVQARRRHAY
     AEQLRLLDRA LELWDDAPTE VRQGVRPVDY AEAYPACGCH DGDALRFLDL LAEIAVAARL
     SGDIERAFTI TKRALRSLRS ESDPLRTAWF LVQRSRLCQG TGRGNGWEDL GTAQELVRGL
     PPSSVHAEVL AAVASWEVLH EPGPGTFATA ERAVELAQLV GDEEAELNSR LTLAGLRVDA
     GDVDEGIAEF RTSLARAVDR GYFAVIGRGQ VNLASALEGV GRSREAVEVT DQGVELTTRY
     GLKDSTSWVL GNRAESLQSL GRWEEAGRAA ADARRLAQNP RAIALAASRR TDLALDEGDL
     AEAERELAVA QEYYGTHDPQ PQHALVMARH ALRIAARQGR LLDARSILQQ ALDAGFPPGT
     QRYTWPLLWA ATTAEADARG LPAAEPGRPA ILARIRDAAK RLPRICPVWS AYDRAVDAEL
     RRAEGRETPD AWAEAVAAFE PLERPHELAR ACYRWAESLL HGSERATVGL HGRTPREAAV
     LLLTQAHTAA VTMGARPLAD ELELLAQRAR VPLPGLIPDA TAGTAPGRTR ATAEAPAPSA
     APAESLGLTP REREVLRLVA DGRSNRQIAD ALFISPKTAS VHVSNILAKL GVSGRGEAGA
     VAHRLRLFGE PAAG
//