ID A0A0P4R5C3_9ACTN Unreviewed; 2286 AA.
AC A0A0P4R5C3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Hint domain-containing protein {ECO:0000259|SMART:SM00306};
GN ORFNames=TPA0598_03_07270 {ECO:0000313|EMBL:GAO08266.1};
OS Streptomyces lydicamycinicus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1546107 {ECO:0000313|EMBL:GAO08266.1, ECO:0000313|Proteomes:UP000048965};
RN [1] {ECO:0000313|Proteomes:UP000048965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 110027 {ECO:0000313|Proteomes:UP000048965};
RA Komaki H., Ichikawa N., Katano-Makiyama Y., Hosoyama A., Hashimoto M.,
RA Uohara A., Kitahashi Y., Ohji S., Kimura A., Yamazoe A., Igarashi Y.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Streptomyces sp. NBRC 110027.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GAO08266.1, ECO:0000313|Proteomes:UP000048965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 110027 {ECO:0000313|EMBL:GAO08266.1,
RC ECO:0000313|Proteomes:UP000048965};
RX PubMed=26380643; DOI=10.1186/s40793-015-0046-5;
RA Komaki H., Ichikawa N., Hosoyama A., Fujita N., Igarashi Y.;
RT "Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a
RT producer of anti-MRSA antibiotic lydicamycins.";
RL Stand. Genomic Sci. 10:58-58(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAO08266.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BBNO01000003; GAO08266.1; -; Genomic_DNA.
DR Proteomes; UP000048965; Unassembled WGS sequence.
DR CDD; cd00081; Hint; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 1.
DR PANTHER; PTHR32305; -; 1.
DR PANTHER; PTHR32305:SF17; TRNA NUCLEASE WAPA; 1.
DR Pfam; PF07591; PT-HINT; 1.
DR Pfam; PF05593; RHS_repeat; 1.
DR SMART; SM00306; HintN; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000048965};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..2286
FT /note="Hint domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038476677"
FT DOMAIN 2047..2148
FT /note="Hint"
FT /evidence="ECO:0000259|SMART:SM00306"
FT REGION 40..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1628..1678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2028..2049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2286 AA; 247024 MW; FEB4DE391209E059 CRC64;
MNGTLGLFRR ARLRRSLAVG ISTVLAGSLL PVLPSAAQPA SATETSNRPY AGKAVDGTYG
IRARPRKLPT GPRTPTERPK SRWPKAATAT ISLANPGIAG PPKKANGRGE AFPLTLAAAD
ARSDKSAKAT GTHRSAVPGS VTARILGQRW ARKAGIDGMP FTLQPAARST ATDPQRPGPL
RVGVDYGAFA GAHGGNYASR LRLVELPACA ATAPDKAECR TAKPLATRND TEKHTLTASS
VPLRAKGPTV LAAVGDDKSV KGDYKATSLS PSATWNTNLN TGDFTWSYDM PVPEVPGGLK
PSVGLSYSSG SIDGRTGNSN NQGSWAGDGF ELWPGYIERR YKPCADDGEK HTDGSKPADL
CWGYDNAFIS FNGKAGELVP AGKDEWKLQN DDGTRIKRLT SSARDNGDND NEYWELTEPS
GTRFYFGYHK LPGWAAGKDT TDSTWTVPVF GNDSGEDCHK DAFKDSWCRQ AWRWNLDYVV
DPHGNAISYY YDKETNSYGR DLNKDDDTPY TRGGYLKRIE YGRTSADLYA GKPLARVSFA
NSERCLPQSG VTCAADTIDA KSFYWYDTPW DLNCKAGTAC DQGRLSPTFW TRKRLTGVTT
EVLKDGALTP VDSWALAHRW GKADVDYQLE LESIQHTGHT DTKPLTLPKT TFAYTQLANR
LDKTGDGYAP YIKDRLSTIA DEYGGQTDVN YSKPACSFSN LPTPESNTTR CFPQFIGGSS
SDDMDREWFN KYVVESVTTT DRTGGAPDQV TRYDYRDDAA WHYDDDDGLT KEKFKTWSQW
RGYGHVRVQT GGQGTSADAM KTQEDSYFLR GMDGDRKNTG GGTKDVSVSL SAGEGEPLTD
DASAAGFAYK TATYSAPGGK VLTKTVSRPW HHQTAKKTRD WGTVTANFSG TASARAWTSL
DDGAGAKWRT TTTASTFDTV AGRVKEVSDR GDDSTTDDDR CTRTTYATNT DKNILTLPAR
VETVATECGS SPDRTKQVIS DVRTAYDGGG YGAAPTKGDA TAVAKLKKHD GTTATYLETG
TTYDGYGRPE KVTDLTANVT AIGDSAPTRT ARTDGRTTTT AYTPATGFPT KTVTTTPPAD
AKDAATAQAT TTELDPLRGL PAATVDTNGK RTTRTYDALG RSLKVWLPDR ARTTVLLPNY
QFDYYVEDGK PATVATRTLN PEGASQAVSY TLYDGYLRPR QTQAPGPDAG WLISDTFYDE
RGLATKTFAP YYVAKKPERE LFKPADALSV ETQTWKTYDG LGRETESRDV AGNGEGGKVL
AVTTTRYSGD RTTVIPPAGG TATTTVTDAR GQTTQLLRHR TRAADAPAET TRYSYTPAGK
LEGVTDPAGN TWAYQYDQLG NQTWSKDPDK GITKATFDDR SRQIASEDAN GAVLATVYDG
LGRKTELHDK TPDGPLRAKW VYDTVTKAKG QLAESTRYLD GKPYTNKIIQ YDPVYRPLRT
ATVIPESEGA LAGTYMASTN FYSNGQPQGR GTAAAGNLPA QVWNYEYADN TLRTTAVYNS
GIRSDATYTL TGKPLTYKIV GNGKPTQLTN TYEWGTQRLS NSRVDRQDVA GVDQSATYGY
DPAGNVTSLS DVSRTGTDTQ CFTYDHLRRL TDAWTQDEKT CAAAPAGNLI AGPAPYWHSY
AYDSAGNRTS LTQHDPSGDP AKDSKSTYTY PKPGTHQPHT LTSVDTTGPT GTSKSSYDYD
ALGNTTRRLL HGDQQSLHWD VEGHLTKVTQ PAGDNGTKTT SYVYDADGNR LITRTGDRTT
LTLGDHTELT LDKGAAKPKA TRYIPLGGGN QAVLADDGTY TVTLADRLGT GQLAINAADQ
SLTQRRSLPF GGLRGAKPTN WPGSKGYVGG TDDTADTGLT HLGAREYDPE TGRFLSVDPL
MNLADSESLN GYTYAGSTPM TDSDPSGLMR PAESGAKGCD PVLCPWMDWG SKQDRQRFLN
GLAAINPAKW GGYRSHPQAA VLPGLWVEST WEHSDEFTNA IYAEATSRQL FYQGMFEIDP
REGSTQLTLA NLKFGVCAEM EGHCPESFAQ LLLSSMASGA MTFAGSRDGG GIRAGGSRRG
DTTSPCPHSF LPGTEVALAD GEKKNIEDVT TGDKVVATDP ETGKTTTRPV VATIVTKDDK
HFTDLTITTP TGDSSIIATD THPFWSIDKK KWIDAGDLRP GTQLRTPQGT IAKITAVRHF
HKKQRTHDLT IAGTHTYYVL AGATPVLVHN SDCPRTPIGG RGRPLDINTP NKPATIDGRD
YTGHALDRMQ RQGIMSSAVE NATRGTPIPG KNAGTTAFYD EANDMTVITD TGSGRVITVD
YGRIRQ
//
