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Database: UniProt
Entry: A0A0P4RBZ3_9ACTN
LinkDB: A0A0P4RBZ3_9ACTN
Original site: A0A0P4RBZ3_9ACTN 
ID   A0A0P4RBZ3_9ACTN        Unreviewed;       248 AA.
AC   A0A0P4RBZ3;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   SubName: Full=RNA polymerase ECF-type sigma factor {ECO:0000313|EMBL:GAO11092.1};
GN   ORFNames=TPA0598_08_00030 {ECO:0000313|EMBL:GAO11092.1};
OS   Streptomyces lydicamycinicus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1546107 {ECO:0000313|EMBL:GAO11092.1, ECO:0000313|Proteomes:UP000048965};
RN   [1] {ECO:0000313|Proteomes:UP000048965}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 110027 {ECO:0000313|Proteomes:UP000048965};
RA   Komaki H., Ichikawa N., Katano-Makiyama Y., Hosoyama A., Hashimoto M.,
RA   Uohara A., Kitahashi Y., Ohji S., Kimura A., Yamazoe A., Igarashi Y.,
RA   Fujita N.;
RT   "Whole genome shotgun sequence of Streptomyces sp. NBRC 110027.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:GAO11092.1, ECO:0000313|Proteomes:UP000048965}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 110027 {ECO:0000313|EMBL:GAO11092.1,
RC   ECO:0000313|Proteomes:UP000048965};
RX   PubMed=26380643; DOI=10.1186/s40793-015-0046-5;
RA   Komaki H., Ichikawa N., Hosoyama A., Fujita N., Igarashi Y.;
RT   "Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a
RT   producer of anti-MRSA antibiotic lydicamycins.";
RL   Stand. Genomic Sci. 10:58-58(2015).
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. ECF subfamily.
CC       {ECO:0000256|ARBA:ARBA00010641}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAO11092.1}.
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DR   EMBL; BBNO01000008; GAO11092.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0P4RBZ3; -.
DR   OrthoDB; 5244716at2; -.
DR   Proteomes; UP000048965; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:InterPro.
DR   GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR   CDD; cd06171; Sigma70_r4; 1.
DR   Gene3D; 1.10.1740.10; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR039425; RNA_pol_sigma-70-like.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR013249; RNA_pol_sigma70_r4_t2.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   NCBIfam; TIGR02937; sigma70-ECF; 1.
DR   PANTHER; PTHR43133:SF53; ECF RNA POLYMERASE SIGMA-E FACTOR; 1.
DR   PANTHER; PTHR43133; RNA POLYMERASE ECF-TYPE SIGMA FACTO; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF08281; Sigma70_r4_2; 1.
DR   SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1.
DR   SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000048965};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          61..126
FT                   /note="RNA polymerase sigma-70 region 2"
FT                   /evidence="ECO:0000259|Pfam:PF04542"
FT   DOMAIN          182..230
FT                   /note="RNA polymerase sigma factor 70 region 4 type 2"
FT                   /evidence="ECO:0000259|Pfam:PF08281"
FT   REGION          123..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   248 AA;  27553 MW;  9CC080A012AE2FB9 CRC64;
     MTVATGSPAW ERPARYGRWG RAVEPTQVDR PGGKSSLPPD EVLVEQLRAG DETAFRLMLD
     AWSRSMLRLA RSFVSTNATA EEVLQDTWLA VIRGLDGFQG RASLRSWVYR ILINTAKDRG
     RKESRTLPWT SLAPEGSGPT AEPTRSQRPD DAYPGHWCTG AGSVSWLMPE GAALAAEVRA
     VIAAALEELP TRQRAVVMLR DVEGYEVQEV CSLLEISHGN QRVLLYRGRT FVRDRLKEYL
     AKAESDVT
//
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