ID   A0A0P4RC22_9ACTN        Unreviewed;       929 AA.
AC   A0A0P4RC22;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Putative LuxR family transcriptional regulator {ECO:0000313|EMBL:GAO11133.1};
GN   ORFNames=TPA0598_08_00440 {ECO:0000313|EMBL:GAO11133.1};
OS   Streptomyces lydicamycinicus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1546107 {ECO:0000313|EMBL:GAO11133.1, ECO:0000313|Proteomes:UP000048965};
RN   [1] {ECO:0000313|Proteomes:UP000048965}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 110027 {ECO:0000313|Proteomes:UP000048965};
RA   Komaki H., Ichikawa N., Katano-Makiyama Y., Hosoyama A., Hashimoto M.,
RA   Uohara A., Kitahashi Y., Ohji S., Kimura A., Yamazoe A., Igarashi Y.,
RA   Fujita N.;
RT   "Whole genome shotgun sequence of Streptomyces sp. NBRC 110027.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:GAO11133.1, ECO:0000313|Proteomes:UP000048965}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 110027 {ECO:0000313|EMBL:GAO11133.1,
RC   ECO:0000313|Proteomes:UP000048965};
RX   PubMed=26380643; DOI=10.1186/s40793-015-0046-5;
RA   Komaki H., Ichikawa N., Hosoyama A., Fujita N., Igarashi Y.;
RT   "Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a
RT   producer of anti-MRSA antibiotic lydicamycins.";
RL   Stand. Genomic Sci. 10:58-58(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAO11133.1}.
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DR   EMBL; BBNO01000008; GAO11133.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0P4RC22; -.
DR   Proteomes; UP000048965; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000048965}.
FT   DOMAIN          855..920
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50043"
SQ   SEQUENCE   929 AA;  98922 MW;  335C97B5595759C6 CRC64;
     MESTLAGEGQ AAFVVGEAGL GKTAVLEQAA AAAERRSLRV LRGSAQEREQ ACPFAFISSC
     LRLEESPSDA RRARVAEVLR GDARYGLPGA KGETAGAYAA TIEAMIGLVE DLCAQGPLAL
     FLDDLQWADS ASVAVLHKLV CSVHQLPLLV VGAHRPVSGV GEVDQLSRSP IAGNRILLEL
     APLDTKAVVA LLADLCGRPA GPRLRRMAEG AAGNPLYLTE LIAALRREHA IETGEATADI
     AAGCSLPSLT ALVTHRLRYL RDDVLQMLRV ASVLGAGCTT AELAAVVDLP LRDLLAVMAE
     AEASGVLRDT GQRLRFRHEL IRHALYDAVP GSVRAMLHMR AAQCLAEAGA APERVAEHLL
     NGLPSPDFLI TWLEGSAARL TTRAPAMALR LLTTALELGD PMDAGYANLR LHHALAQLSC
     GLLAEAEESA RCALAKAPDP GWESLMRWIV IQAAFARGRP DLALAEARAG CRSPDVPAIE
     AVRLQAFGAV CLFALGDLTE AGAVASRARR AADKAGDSHA LAGALHVLAA KRFLETPDAE
     AVELARQASR LTPDTMHPAQ WMGLQLALVN YYVDLDLGHD AQRTLAAIRI PAEHTGGMFL
     PWYHLSCALL AFHTGRWDDA LAEIASGLDC GGQDALSRAL RALAALIAVH RGSRPLAEAH
     LTALLSEDDN STVAAFYEYL PLCAGVLLDE AQGDAQRAYS RLVEAFDSGV GHLPGQLILS
     FLTPDLVRLA LAQGDHTNAQ RYAAAAQRRA DHSGGLYHLG DAYRCQGLLS GDPDLLMEAV
     RCYRNAPRPL NEAHALTDAA ELLARGGRLD DARVLLDQAL DTFAQMGAVW DVAQATSRLR
     AVAVRRGSHR TRTGCRDGWE ALTHTERLVA AHVAEGCSNP EIAARLSIAR STVSTHVSSI
     LRKLAMTSRV EIAAEVTRRQ KSGRSPSQD
//