ID A0A0P4RGP4_9ACTN Unreviewed; 860 AA.
AC A0A0P4RGP4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Putative ABC transporter ATP-binding/permease protein {ECO:0000313|EMBL:GAO12457.1};
GN ORFNames=TPA0598_11_00180 {ECO:0000313|EMBL:GAO12457.1};
OS Streptomyces lydicamycinicus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1546107 {ECO:0000313|EMBL:GAO12457.1, ECO:0000313|Proteomes:UP000048965};
RN [1] {ECO:0000313|Proteomes:UP000048965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 110027 {ECO:0000313|Proteomes:UP000048965};
RA Komaki H., Ichikawa N., Katano-Makiyama Y., Hosoyama A., Hashimoto M.,
RA Uohara A., Kitahashi Y., Ohji S., Kimura A., Yamazoe A., Igarashi Y.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Streptomyces sp. NBRC 110027.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GAO12457.1, ECO:0000313|Proteomes:UP000048965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 110027 {ECO:0000313|EMBL:GAO12457.1,
RC ECO:0000313|Proteomes:UP000048965};
RX PubMed=26380643; DOI=10.1186/s40793-015-0046-5;
RA Komaki H., Ichikawa N., Hosoyama A., Fujita N., Igarashi Y.;
RT "Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a
RT producer of anti-MRSA antibiotic lydicamycins.";
RL Stand. Genomic Sci. 10:58-58(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAO12457.1}.
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DR EMBL; BBNO01000011; GAO12457.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P4RGP4; -.
DR Proteomes; UP000048965; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03213; ABCG_EPDR; 1.
DR CDD; cd00060; FHA; 1.
DR Gene3D; 2.60.200.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR48041:SF91; ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A; 1.
DR PANTHER; PTHR48041; ABC TRANSPORTER G FAMILY MEMBER 28; 1.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF00498; FHA; 2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00240; FHA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:GAO12457.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000048965};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 603..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..70
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 209..259
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 291..532
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 77..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 860 AA; 94168 MW; 92472155430BE15A CRC64;
MPELVLELNG RTWTLDPSRS YNVGRDPQGD MVLDDARVSW RHATVRWAGR SWIIEDQGST
NGTYAQGQRI HQMEIGPGST VHLGNATDGP RVTLSAPAAG AFSAPPASAP QQQAAQGWQA
PPAHQQPPAQ QPPAHQPPAQ QGWQAPPQAQ QQPYLPPQQA QQPQHAQQAV PPQQARPPQE
RPAQKAGGGP VHGDRSPTTF HRLDMGRVMR IGRALENELV VSDLQVSRHH AEFRATPDGR
FEIHDLGSHN GTYVNGQPVP KSGKAPVGPN DIIGVGHSTF RLVGDRLEEF VDTGEVSFSA
RHLTVTVDGG KQILKDVSFG VPEKSLIAVI GPSGSGKSTL LKALTGYRPA NQGDVLYDNR
NLYKQFAELR QRIGLVPQDD ILHKELTVQK ALRYAAKLRF PGDTAESERE ARIDEVLREL
KLDVHKDKRV TSLSGGQRKR VSVALELLTK PSLIFLDEPT SGLDPGMDRD VMQLLRGLAD
DGRTVLVVTH SVAELGLCDK LLVMAPGGGV AYFGPPDEAL NFFQYDTWAD VFSAFENYRD
YDWMGRWRGS PHYQMYAADI DAVAPQSVNV QVPPARIQKS QSWGSQLWTL MRRYVSVLAS
DRGFLGLMLI LPAVLGVVSM LIPSDYGLGY GPLNRHRTNR DASTIMLILA VGMCFSGAAN
SVRELIKERV IYERERATGL SRSAYLMSKV IVLGVVTAIQ GVIIAAIGFS TRNMPEEGLL
VAKAPAIEMA LAIIALGFTS MMFGLIISAL VKTAEKTMPL LVMFAIVQVV FTGVLFQLFD
TVGVAQFAWL MPSRWAVGAM GATADMNTLL PWEPGNPDPL WKHQTGVYVM DMIILITLGV
ALAFVVARLL RRHEPEVMRK
//
