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Database: UniProt
Entry: A0A0P4UV44_9CYAN
LinkDB: A0A0P4UV44_9CYAN
Original site: A0A0P4UV44_9CYAN 
ID   A0A0P4UV44_9CYAN        Unreviewed;       618 AA.
AC   A0A0P4UV44;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   10-OCT-2018, entry version 18.
DE   RecName: Full=Malto-oligosyltrehalose trehalohydrolase {ECO:0000256|PIRNR:PIRNR006337};
DE            Short=MTHase {ECO:0000256|PIRNR:PIRNR006337};
DE            EC=3.2.1.141 {ECO:0000256|PIRNR:PIRNR006337};
DE   AltName: Full=4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase {ECO:0000256|PIRNR:PIRNR006337};
DE   AltName: Full=Maltooligosyl trehalose trehalohydrolase {ECO:0000256|PIRNR:PIRNR006337};
GN   ORFNames=NIES2104_20480 {ECO:0000313|EMBL:GAP95526.1};
OS   Leptolyngbya sp. NIES-2104.
OC   Bacteria; Cyanobacteria; Synechococcales; Leptolyngbyaceae;
OC   Leptolyngbya.
OX   NCBI_TaxID=1552121 {ECO:0000313|EMBL:GAP95526.1, ECO:0000313|Proteomes:UP000052243};
RN   [1] {ECO:0000313|EMBL:GAP95526.1, ECO:0000313|Proteomes:UP000052243}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-2104 {ECO:0000313|EMBL:GAP95526.1,
RC   ECO:0000313|Proteomes:UP000052243};
RX   PubMed=26494835; DOI=10.1093/dnares/dsv022;
RA   Shimura Y., Hirose Y., Misawa N., Osana Y., Katoh H., Yamaguchi H.,
RA   Kawachi M.;
RT   "Comparison of the terrestrial cyanobacterium Leptolyngbya sp. NIES-
RT   2104 and the freshwater Leptolyngbya boryana PCC 6306 genomes.";
RL   DNA Res. 22:403-412(2015).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of (1->4)-alpha-D-glucosidic
CC       linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to
CC       yield trehalose and (1->4)-alpha-D-glucan.
CC       {ECO:0000256|PIRNR:PIRNR006337}.
CC   -!- PATHWAY: Glycan biosynthesis; trehalose biosynthesis.
CC       {ECO:0000256|PIRNR:PIRNR006337}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRSR:PIRSR006337-1}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family.
CC       {ECO:0000256|PIRNR:PIRNR006337, ECO:0000256|SAAS:SAAS00964676}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAP95526.1}.
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DR   EMBL; BBWW01000001; GAP95526.1; -; Genomic_DNA.
DR   RefSeq; WP_058997877.1; NZ_BBWW01000001.1.
DR   EnsemblBacteria; GAP95526; GAP95526; NIES2104_20480.
DR   UniPathway; UPA00299; -.
DR   Proteomes; UP000052243; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0033942; F:4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005992; P:trehalose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR022567; DUF3459.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR004193; Glyco_hydro_13_N.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR012768; Trehalose_TreZ.
DR   Pfam; PF00128; Alpha-amylase; 1.
DR   Pfam; PF02922; CBM_48; 1.
DR   Pfam; PF11941; DUF3459; 1.
DR   PIRSF; PIRSF006337; Trehalose_TreZ; 1.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   TIGRFAMs; TIGR02402; trehalose_TreZ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000052243};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR006337,
KW   ECO:0000313|EMBL:GAP95526.1};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR006337,
KW   ECO:0000313|EMBL:GAP95526.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052243}.
FT   DOMAIN       84    462       Aamy. {ECO:0000259|SMART:SM00642}.
FT   ACT_SITE    264    264       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006337-1}.
FT   ACT_SITE    301    301       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006337-1}.
FT   SITE        395    395       Transition state stabilizer.
FT                                {ECO:0000256|PIRSR:PIRSR006337-3}.
SQ   SEQUENCE   618 AA;  71020 MW;  BC4280D2201FDEB9 CRC64;
     MKVGAWYLGD YRAEFTVWAP RSQTVTLELP DRSIELIQKN EGYWSAIVSD IQPGTQYRYR
     LDDQQLYPDP ASLSQPFGVH EASELVDHHF EWNDSEWTGI ALEDLVIYEL HVGTFTPEGS
     FEAIIPRLQT LKELGITAIE LMPIAQFPGD SKTDDPKAYR NWGYDGTYPY AAQNSYGGVA
     GLKKLVDACH QHGLSVVLDV VYNHFGPEGT YIHQFGDYFT EVYKTPWGKA INYDDAYSHC
     VRSYFLENAL YWLREFHIDA LRLDAVQAIY DLGARHFLAE LADRVDELSQ QQNRKLYLIA
     ESDLNDAKLI RPKNANGYGL DAQWSDDFHH ALHALLTGTD IGYYQDFGTC EHLAKAYRDT
     FVYDWKYAPH RNRFHGAPAL DRSMTQFVVC IQNHDQIGNQ MLGERLADLI SFEGLKLAAG
     AVILSPYIPL LFMGEEYGEE VPFTYFVSHS DPDLIRMVRQ GRKQEFKHFH YDGEPLDPEA
     KETFDTCILQ WERHQEGKHK TLWQFYQKLL EMRRSMPAFV NRDRNSLSAC AEDDKKFVWV
     ERSSTKQTLL TLMSFNQSEQ SFEFPEGRWR KVFDSSDECW MGKGALPSAH ASVTAPEKGE
     HGEAGQVSGQ SFVIYERI
//
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