ID   A0A0P5THC1_9CRUS        Unreviewed;       380 AA.
AC   A0A0P5THC1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=APZ42_014418 {ECO:0000313|EMBL:KZS19215.1};
OS   Daphnia magna.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX   NCBI_TaxID=35525 {ECO:0000313|EMBL:JAL71608.1};
RN   [1] {ECO:0000313|EMBL:JAL71608.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Gilbert D., Podicheti R., Orsini L., Colbourne J., Pfrender M.;
RT   "Daphnia magna gene sets from two clonal populations assembled and
RT   annotated with EvidentialGene.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:JAL71608.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KZS19215.1, ECO:0000313|Proteomes:UP000076858}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Xinb3 {ECO:0000313|EMBL:KZS19215.1,
RC   ECO:0000313|Proteomes:UP000076858};
RC   TISSUE=Complete organism {ECO:0000313|EMBL:KZS19215.1};
RA   Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT   "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. {ECO:0000256|ARBA:ARBA00008685}.
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DR   EMBL; GDIP01132106; JAL71608.1; -; Transcribed_RNA.
DR   EMBL; LRGB01000412; KZS19215.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0P5THC1; -.
DR   STRING; 35525.A0A0P5THC1; -.
DR   Proteomes; UP000076858; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR001320; Iontro_rcpt_C.
DR   PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR   PANTHER; PTHR42643:SF24; IONOTROPIC RECEPTOR 31A, ISOFORM C-RELATED; 1.
DR   Pfam; PF00060; Lig_chan; 1.
DR   Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076858};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        85..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        149..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        351..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          4..70
FT                   /note="Ionotropic glutamate receptor L-glutamate and
FT                   glycine-binding"
FT                   /evidence="ECO:0000259|Pfam:PF10613"
FT   DOMAIN          91..361
FT                   /note="Ionotropic glutamate receptor C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00060"
SQ   SEQUENCE   380 AA;  42986 MW;  8A66737175C5C2A1 CRC64;
     MERRYKISII RENTNGVKRN GSWNGIIGTL QREEADLGLS PFAISLERYE AIEFCGSITG
     DSTGILVKYP EPIVSSTSAI EVFSIGVWIG WIISAAAVVG ISVILSHISK KFKVEADERG
     VVSHDSFAWY LYGVLISQGS YLPSCPWPLK LLAATWCIVA FVFVNIYNST LTSYMSVTYQ
     RPLINSFSDL AASSTFKATV LTGSIQDIDL LGSNSGVLKT LADKIQKCSP DCRRFNLNEM
     FALVLGEEPY VSIVPWTVGI AALKKHNLER EKCRLAMAHE TMSWKPMFMG VPKTSPYIEE
     INRESLWFID TALFDYLHAQ YLKKPSQCRL NYNAKGVSTK TFKNRVILKQ FYLPFLILFC
     GYFLAFLQFL REKVCFFFHF
//