ID A0A0P5VHB4_9CRUS Unreviewed; 492 AA.
AC A0A0P5VHB4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Phosphatidylinositol 4-kinase type 2 {ECO:0000256|RuleBase:RU367084};
DE EC=2.7.1.67 {ECO:0000256|RuleBase:RU367084};
GN ORFNames=APZ42_012796 {ECO:0000313|EMBL:KZS20443.1};
OS Daphnia magna.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=35525 {ECO:0000313|EMBL:JAM03778.1};
RN [1] {ECO:0000313|EMBL:JAM03778.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D., Podicheti R., Orsini L., Colbourne J., Pfrender M.;
RT "Daphnia magna gene sets from two clonal populations assembled and
RT annotated with EvidentialGene.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAK41216.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D.G.;
RT "EvidentialGene: Evidence-directed Construction of Complete mRNA
RT Transcriptomes without Genomes.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:JAM03778.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KZS20443.1, ECO:0000313|Proteomes:UP000076858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinb3 {ECO:0000313|EMBL:KZS20443.1,
RC ECO:0000313|Proteomes:UP000076858};
RC TISSUE=Complete organism {ECO:0000313|EMBL:KZS20443.1};
RA Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|RuleBase:RU367084};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU367084};
CC Peripheral membrane protein {ECO:0000256|RuleBase:RU367084}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00008941,
CC ECO:0000256|RuleBase:RU367084}.
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DR EMBL; GDIP01145992; JAJ77410.1; -; Transcribed_RNA.
DR EMBL; GDIQ01210509; JAK41216.1; -; Transcribed_RNA.
DR EMBL; GDIQ01145341; JAL06385.1; -; Transcribed_RNA.
DR EMBL; GDIP01099937; JAM03778.1; -; Transcribed_RNA.
DR EMBL; LRGB01000190; KZS20443.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P5VHB4; -.
DR STRING; 35525.A0A0P5VHB4; -.
DR EnsemblMetazoa; XM_032933070.2; XP_032788961.2; LOC116926240.
DR Proteomes; UP000076858; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR039756; Lsb6/PI4K2.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR PANTHER; PTHR12865:SF1; PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2; 1.
DR PANTHER; PTHR12865; PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU367084};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|RuleBase:RU367084, ECO:0000313|EMBL:JAM03778.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367084};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU367084};
KW Reference proteome {ECO:0000313|Proteomes:UP000076858};
KW Transferase {ECO:0000256|RuleBase:RU367084}.
FT DOMAIN 131..460
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 28..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 57..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 56466 MW; D141805A970B4CF1 CRC64;
MSSVNNTRTE LLVDVELVSV EAISTTLVEN SSTEEQPLHQ NNRNHSNGAV VKSYQSTAAT
NKTRTTSSTS DDSALLPDVG YSTIQNSTRG VQEYQPLLNS RMDIDMTFNY FPDDPQFNDI
IRAAELAIEH GIYPERIYQG SSGSYFVKDA EEKIIGVFKP KDEEPYGRLN PKWTKWLHSL
CCPCLFGRSC LVPNQGYLSE AGASIVDQKL GLNVVPRTKV VMLVSETFNY SRIDREKSHV
KKLVSDHFPS VGRRFHRIGL PPKVGSFQLF VEGYKDADYW LRRWESDPLP ETIKKSFQFQ
FEKLVILDFI IRNTDRGNDN WLIKYEKPEV KTTNEEDDWS IVKLPEVKIA AIDNGLAFPF
KHPDSWRAYP FHWAWLPYAK TPFSTEIKEL ILPLISDMNV VQDLCDELYA IFKEDKGFDR
HMFERQMGVM RGQLLNLSQA LKDGKSPVQL VQMPPVIVER SKGHVGTTAA FRNFSDTFTQ
RFQYKGPVFS WW
//
