ID A0A0P6WP54_9BACI Unreviewed; 1176 AA.
AC A0A0P6WP54;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=AM506_18690 {ECO:0000313|EMBL:KPL58069.1};
OS Rossellomorea vietnamensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Rossellomorea.
OX NCBI_TaxID=218284 {ECO:0000313|EMBL:KPL58069.1, ECO:0000313|Proteomes:UP000050398};
RN [1] {ECO:0000313|EMBL:KPL58069.1, ECO:0000313|Proteomes:UP000050398}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCD-SED5 {ECO:0000313|EMBL:KPL58069.1,
RC ECO:0000313|Proteomes:UP000050398};
RA Lee R.D., Jospin G., Lang J.M., Coil D.A., Eisen J.A.;
RT "Draft Genome Sequence of Bacillus vietnamensis UCD-SED5.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPL58069.1}.
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DR EMBL; LIXZ01000020; KPL58069.1; -; Genomic_DNA.
DR RefSeq; WP_060674217.1; NZ_LIXZ01000020.1.
DR AlphaFoldDB; A0A0P6WP54; -.
DR PATRIC; fig|218284.4.peg.1960; -.
DR eggNOG; COG1197; Bacteria.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000050398; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR CDD; cd18810; SF2_C_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000050398}.
FT DOMAIN 638..799
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 820..974
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1176 AA; 133845 MW; 3CC0FC4810658C0E CRC64;
MKGILKQVHQ SEELQSIIAG VEERLSEQLV AGLSGSSRTA YIADVYLQTN KSTVVVTHNL
FQAQKVYDDL IQFLSEDEVY LYSANELIAA ELSVASPELR AQRIEVMNKL SNHQQGVYIV
PVAGLRKILP PKSMWATNQI SFQMGEDIDL DEVLNQLVQM GYQRTGMVST PGEFSLRGGI
VDIFPLTTQN PVRIELFDTE IDSIRLFSVE DQRSIDKLNE IEIGPATEVL LKYENMERLI
HEINAGLSTS LKKVKSAAVK EKMTEYIGHE VGQLENGEVP EQIFKYLSLA YDKPSSLLDY
LPEDGVLFFD EYSRVQEMSE SLEKEEAEWY TSLLQEGQII HDVHVSHTFS SLVSKTKLPK
VYFSLFLRHI PNTSPQNIFN VSTKPMQNFH GQMNVLKAEL DRWKKGKYTV VLLGPDQERV
KKLQRVLDDY KIEIAFVEDG DKLLSGTIQM INGSLTSGFE LPLQKLAVIT EEELFNKKTK
KKPRRQKLSN AERIKSYSEL KVGDHVVHVN HGIGKFLGIE TLEINGVHKD YLHVKYQGND
KLYVPVDQIE LVQKYVASEN KDPKLYKLGG SEWKKVKSKV QSSVQDIADD LIKLYAEREA
AKGYAFSPDG DMQREFEMAF PYEETDDQLR SVSEIKLDME RERPMDRLLC GDVGYGKTEV
AIRAAFKAIA DGKQVAILVP TTILAQQHFE TIKERFQDFP VEIGLLSRFR TRKQQQETTK
GLKNGTVDIV VGTHRLLSKD IQYRDIGLLI IDEEQRFGVT HKEKIKQLKT NIDVLTLTAT
PIPRTLHMSM LGVRDLSVIE TPPENRFPVQ TYVMEYNGAL IKEAIEREMA RNGQVYFLYN
RVEDIERKAD EISMLVPDAR IAYAHGQMSE NELEAVILSF LAGEYDVLVT TTIIETGVDI
PNVNTLIVFD ADRMGLSQLY QLRGRVGRSN RVAYAYFTYR KDKVLTEVAE KRLQAIKEFT
ELGSGFKIAM RDLTIRGAGN LLGAQQHGFI DSVGFDLYSQ MLKEAIEERK GDLPKQPESS
FEVDIEIDAY IPDDYIKDGH QKIEMYKRFR SLSSLPEIEE LEEEILDRFG EYPEEVGYLF
LISEMKIYAK NTKLESIKQD KKTVNIFMSP EGTAQIDGSK VFNLCNKHGR AVGLGMEGSK
LKISINTARL EASKWFNMAY DIIKHLDEAV KIEESV
//
