ID A0A0P6XHH4_9CHLR Unreviewed; 696 AA.
AC A0A0P6XHH4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Penicillin-binding protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=SE15_11260 {ECO:0000313|EMBL:KPL82665.1};
OS Thermanaerothrix daxensis.
OC Bacteria; Chloroflexota; Anaerolineae; Anaerolineales; Anaerolineaceae;
OC Thermanaerothrix.
OX NCBI_TaxID=869279 {ECO:0000313|EMBL:KPL82665.1, ECO:0000313|Proteomes:UP000050544};
RN [1] {ECO:0000313|EMBL:KPL82665.1, ECO:0000313|Proteomes:UP000050544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GNS-1 {ECO:0000313|EMBL:KPL82665.1,
RC ECO:0000313|Proteomes:UP000050544};
RA Hemp J., Ward L.M., Pace L.A., Fischer W.W.;
RT "Whole genome sequence of Thermanaerothrix daxensis DSM 23592.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPL82665.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LGKO01000005; KPL82665.1; -; Genomic_DNA.
DR RefSeq; WP_054522197.1; NZ_LGKO01000005.1.
DR AlphaFoldDB; A0A0P6XHH4; -.
DR STRING; 869279.SE15_11260; -.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000050544; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000050544};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..253
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 301..678
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 696 AA; 77366 MW; F48EC39BD0657CCF CRC64;
MHEPMEHPHP FEHWRLTVFY AAIAFVIGFY LLRLFNLQIL QGANYRIRAE DNRTMEVSIP
TQRGLIYDRN GYILAKNVPS YNVVITPAEL PADEGGIQEV YRQLSQLIGV PVNNGEINEE
TVRNFTPCAT DLGIAQIVYI GDTNAPYSPI RIKCNIDQQT AMIIRERAAD LPGVGIEVES
VREYPTGSLT SAVVGFLGPI PASEEADYRA RGFLPNRDKV GFAGVEYSLN DLLIGQNGKR
VVEVDAAGQI LRDLEPPEQP MPGYSIKLTI DTRLQAAAEA ALINWMDRWN RYFGEQRYTS
GVVIAMNPKT GEILAMVSYP SYENNRMARF IPAYYYEQLQ RDPYRPLLNH AISAEHPPGS
VFKLAAALGI LNEGVVTPEQ KINDPGKITV EERYFENDPN PRTRDYVCYI YKTTGGGHGD
LDFIHGLAQS CDVYFYKVGG GYKNEVPKGL NIWRLGEYAK AIGYGRVLGI ELPGEQDGLI
PDPDWKRINV GENWSTGDTY IATIGQGYVL STPLQVLVSM ATIANDGKLM KPTIVREVLD
SEGNVVQPFE PKMLWDITQD PVIHVYDENY LQTGEMKTVA PWVVKKVQEG LREVVVSGTA
STIFEDFPIP SAGKTGTAEY CDNVAQAKNL CQPGNWPAHA WYVGYAPFDN PEIAVVAFVY
NGDEGARLAA PVVRRVMEAY FNLKEVDAES VGGSVP
//
