ID A0A0P7B7H9_9HYPO Unreviewed; 1639 AA.
AC A0A0P7B7H9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Ubiquitin conjugation factor E4 {ECO:0000313|EMBL:KPM36318.1};
GN ORFNames=AK830_g10249 {ECO:0000313|EMBL:KPM36318.1};
OS Neonectria ditissima.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Neonectria.
OX NCBI_TaxID=78410 {ECO:0000313|EMBL:KPM36318.1, ECO:0000313|Proteomes:UP000050424};
RN [1] {ECO:0000313|EMBL:KPM36318.1, ECO:0000313|Proteomes:UP000050424}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R09/05 {ECO:0000313|EMBL:KPM36318.1,
RC ECO:0000313|Proteomes:UP000050424};
RA Gomez-Cortecero A., Harrison R.J., Armitage A.D.;
RT "Draft genome of a European isolate of the apple canker pathogen Neonectria
RT ditissima.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ubiquitin conjugation factor E4 family.
CC {ECO:0000256|ARBA:ARBA00007434}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPM36318.1}.
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DR EMBL; LKCW01000208; KPM36318.1; -; Genomic_DNA.
DR STRING; 78410.A0A0P7B7H9; -.
DR OrthoDB; 1554at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000050424; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0034450; F:ubiquitin-ubiquitin ligase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR019474; Ub_conjug_fac_E4_core.
DR InterPro; IPR045132; UBE4.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR13931:SF2; UBIQUITIN CONJUGATION FACTOR E4 B; 1.
DR PANTHER; PTHR13931; UBIQUITINATION FACTOR E4; 1.
DR Pfam; PF04564; U-box; 1.
DR Pfam; PF10408; Ufd2P_core; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF02176; zf-TRAF; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS51698; U_BOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00207}; Reference proteome {ECO:0000313|Proteomes:UP000050424};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00207};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 185..226
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 323..368
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 1551..1624
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT ZN_FING 323..368
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 406..433
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..23
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1639 AA; 184974 MW; 8E917ECDA8BA485E CRC64;
MPTDQPADEP ADVLPPPETQ PSPPASTVAT TTDPATIATT AAATAARAGH TPLTLLITSD
SESGETEPYH LTPAAIRRLA RRNLRRTSPT PDLVTSLVRP PSPDTLYVGT RAVQNTLRVP
PDGASPGTSQ PAGLLIPNAN SERRSGPLLP PHLSSLNIPK RYGGECIFDL YSLTYVQDPD
VNLLCPICHD PLVDPVTTPC DHTFCYRCLR QSIYTSPSGT ACPVDREPLV WSNCFSAARL
VRTQLNNLVV KCPYHGRGCK EELRREVVEA HATTECRFKD FTCPGTDCDK RLRSKPADHT
CPHREIRCSY CQAEIEAPDR DFHMLSCAMS KTRCETCWRL VRRRQMDSHQ ELECEGVVIV
CQYQEFGCPI RSTRGMMASH TVTCAFHPDT PSGIIIRHQR ELIQSYSDLG QQIQQLNSRQ
DETNRRINEV TVAVARRGGG DSTGGDSRTI QDLDAGFEEV HQNLTHLEAR QSMWTMNQVM
PIREEVTELR NNINMIRMHV NWLLNRSREE GRIRAANNSG SSTMRQDSPG NGGSMLPERR
RSTSQETNLP LGWHPSSRKS SGPVPQIRAR RLAKLGTSTP KSEETKTSEP ESSTPSRAST
PKPQTTPAAE SSRPKINITS AAGSGPNPFA KLGVKDNGKS EPSSSTGSFR PSRKRLASEI
DDAVSADRPP QRTNNAQPES DDDYANRILS HIFRISVDPH HMTDSHGHRL VFLPGLNEEL
NGSGDSLKLS VNSLDQAIME ALGAWPQNKP LMQYLLPCWK RAVKAAATTK LTEGPRFEAH
EEAKRLCMSS CLFALTMPDL YGREPNPKHD TLMPYILQGV QSEDGLCFDF IREAIKRFDE
DEAFPGIFSN AMVQISGKLS SLSMDDDYKP YMQALMTYTR FPPLIVNLAK HPCFKMAQSP
SGIERHTILG PFFRISPLQS EVIQSYFPGA RTLDKARIRN AQDALRMVIR THQDDLFAIA
NAFIRAGPDT RSRTLDWFAY IMNKNHKRRA LQVDHREVAS NGFMINVTAI LDRFCEPFMD
NDFSKIDKID DDYFRKNPRV DIKDETKLNA DQAYSDEYYS KTLPGEPNFI SEAFFLTLAA
HHYGSEACNS QLKNIDRDIK YLEKHVKAME AERPRVANVP HQLRHLEETL TRHTAVLEKT
MGMKYAIEGV LLDERMQSTS LRFMRYVAVW LLRLATRSKY APGLESKEIK LPLPEEKLDT
FSCLPEYALQ NIVDNFKFIF RFLANILPSA VGDEMIALCI TFLRSTDYIK NPYLKSSLVS
LLFSATWPFM HLKRGVLGDQ LISSKFANEH LLHALMKFYI ECESTGADSA FYDKFNIRYE
IFQVIKCVWV NDHYKRQLTQ ESRVNKQFFV QFVNMLLNDS IYVLDEALSK FPKIRLLEKE
LENPSLSAED RQKKEEEHQT MAGQATSFMQ LANETLEMMK LFTDAMSEAF TMPEIVTRLA
GMLNYNLETL AGKKAAAELS VANKDKYHFR PIQLISDIVD IYLNLGNSPV FIDAVAADGR
SYKPEVLDRV SRILTSRHQK DAADIARWDK LKVKFIDAKL IIDQAELDLG EIPTEFEDPI
MGDLMKDPVL LPSRQVVDRS TIVQHLLGDP KDPFTRQPMS IDDAIPQTEL KEKIDKWREE
RMQAAKDKLK EAIMDTTEG
//
