ID A0A0P7B8M8_9HYPO Unreviewed; 866 AA.
AC A0A0P7B8M8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=AK830_g9766 {ECO:0000313|EMBL:KPM36819.1};
OS Neonectria ditissima.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Neonectria.
OX NCBI_TaxID=78410 {ECO:0000313|EMBL:KPM36819.1, ECO:0000313|Proteomes:UP000050424};
RN [1] {ECO:0000313|EMBL:KPM36819.1, ECO:0000313|Proteomes:UP000050424}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R09/05 {ECO:0000313|EMBL:KPM36819.1,
RC ECO:0000313|Proteomes:UP000050424};
RA Gomez-Cortecero A., Harrison R.J., Armitage A.D.;
RT "Draft genome of a European isolate of the apple canker pathogen Neonectria
RT ditissima.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPM36819.1}.
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DR EMBL; LKCW01000189; KPM36819.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7B8M8; -.
DR STRING; 78410.A0A0P7B8M8; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000050424; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF3; CLC CHANNEL; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000050424};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 158..176
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 331..348
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 354..370
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 382..406
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 496..514
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 556..577
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 583..602
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 806..866
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 866 AA; 96462 MW; A200CADCB5D59A53 CRC64;
MADRGRESTG SQPPSPRSVR RPWPASRSHS NQDPDERSPL LTTSRSRIRI GGPSSSKHQN
SSISRDQSYT AGTFHGSRHH SRHPSWGQRL IHALGDRQES SMSESKGSIF PDERVWYDQF
TSTDWVHDAI ADSYRVKELR SRKDVWGRFQ IMFDGAQGWI LSALSGCLVA LMAYVVDVTE
STFFDFKDGY CTRGWYLNER KCCPDDECHD WKTWSEALNH PFGKRWTDFI VYMVCVVVLA
LLACWITLWT KTIVPSAYRL TTLDENLAAE DLPQTYDDAQ GSEASTPRVE PDTTTENPPM
IYYSAAGSGV AEVRVILSGF VLHGFLGVRT LLIKMVALIL SVASGMSLGK EGPYVHMAAC
VGNILCRLFS KYDRNDGKRR EVISAAAAAG VAVAFGAPLG GVLFGLEEVS YFFPAKTLFR
TFFCCIVAAL SLKFLNPYGT QKIVLFQVRY LVDWEYFELG SFIFVGILGG ATGALFIKAS
KYWAQSFRRI KTIKRYPMLE VLLVAVVTGL MSYWNGLTKL PVAELLLNLA APCEGPDVER
EELSLCPKSI DDIPPILLHL LIALLIKGFL TIITFGIKVP AGIYVPSMVV GGLMGRIVGH
LAQWSVLRFP HWAIWGTCAF KSDGTCIQPG VYGLIAAGAT MCGVTRLSVT LAVILFELTG
SLDYVLPFSL AILVSKWIAD AIEPSSIYDL LTNMNSYPFL DNKHKPIFTE NLGDILPRVR
RERIIDITTS PLVPAASLRV KLELLHRSGE LDGGLPILRN GNLVGLIPAP DLGYALDQLE
EESTDLCLMD RIPRIDEDDT FDPTDFTPYI DPAPVALDIR SPMDLVYELF AKLGLRYICV
LKDGKYAGMT HKKTFVRYMR EHEKDE
//
