ID A0A0P7J211_9RHOB Unreviewed; 873 AA.
AC A0A0P7J211;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=AKJ29_02875 {ECO:0000313|EMBL:KPN61665.1};
OS Aliiroseovarius crassostreae.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Aliiroseovarius.
OX NCBI_TaxID=154981 {ECO:0000313|EMBL:KPN61665.1, ECO:0000313|Proteomes:UP000050471};
RN [1] {ECO:0000313|EMBL:KPN61665.1, ECO:0000313|Proteomes:UP000050471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CV919-312 {ECO:0000313|EMBL:KPN61665.1,
RC ECO:0000313|Proteomes:UP000050471};
RA Kessner L., Spinard E., Nelson D.;
RT "Draft genome sequence of Aliiroseovarius crassostreae CV919-312TSm, the
RT causative agent of Roseovarius Oyster Disease (formerly Juvenile Oyster
RT Disease).";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPN61665.1}.
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DR EMBL; LKBA01000025; KPN61665.1; -; Genomic_DNA.
DR RefSeq; WP_055192996.1; NZ_LKBA01000025.1.
DR AlphaFoldDB; A0A0P7J211; -.
DR STRING; 154981.AKJ29_02875; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000050471; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000050471}.
FT DOMAIN 698..714
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 624..631
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 873 AA; 94850 MW; 84BE7C8B36E1CD1E CRC64;
MMAQFLDIKE GYPDALLFYR MGDFYELFFD DAIAAAEALD IALTKRGKHL GKDIPMCGVP
VHSAEGYLLT LIRKGFRVAV CEQLENPAEA KKRGAKSVVK RDVVRLVTPG TLTEESLLDA
RRHNFLAAFA EIREDGAIAW VDISTGAFHV MPCSRMRLSP ELARLAPREV VLPDQIMYDL
DGIVTESGAA PTPLGQAAFD STGAEKRLKE LYAVGSLEAF GSFTRVEIAA MGAIVEYLEI
TQKGKLPLLR PPVRELSHGT LQIDAATRRN LELTHAMSGG RQGSLLSVVD RTVTAGGGRL
LERRISSPSR NLSEIHARLE TVSFLVEQSR ISEDLRESLR KTPDMDRALS RLGLDRGGPR
DLAAIRGGLG AAIDLSEQIA NAEAIPERLM VAGEKLLGHD TLLSLLEEAL VADPPLLARD
GGFIAPGYDE DLDEARKLRD EGRGVIAGMQ AEYAQIAGVS SLKIKHNNVL GYFIETTATH
ADKMLNPPLS ETFIHRQTTA NAVRFTTVAL SELETKIHNA GSRALEIEKR LYSSLTREVL
DRAAAIADTA RALAEIDLAT GFADLARAEG WAMPHVDDSR KFEITGGRHP VVEAALRKTG
EPFIANDCSL SNGNDHAHIW LLTGPNMAGK STFLRQNALI ALLAQTGSFV PAKSAHIGIV
SQLFSRVGAS DDLARGRSTF MVEMVETAAI LNQADDRALV ILDEIGRGTA TYDGLSIAWA
TLEHLHETNR SRALFATHYH EMTQLADKLT GVENATISVK EWEGEVIFLH EVKKGAADRS
YGVQVAKLAG LPEAVIARAN VVLEALEKGE RDGEGAKAMI DDLPLFAATP PAPAPVKTAP
SRVEDALREV LPDSLTPREA LNLVYDLREL LKD
//
