ID   A0A0P7TFM2_SCLFO        Unreviewed;       569 AA.
AC   A0A0P7TFM2;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Mucolipin-1-like {ECO:0000313|EMBL:KPP59590.1};
DE   Flags: Fragment;
GN   ORFNames=Z043_122474 {ECO:0000313|EMBL:KPP59590.1};
OS   Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX   NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP59590.1, ECO:0000313|Proteomes:UP000034805};
RN   [1] {ECO:0000313|EMBL:KPP59590.1, ECO:0000313|Proteomes:UP000034805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Aro1 {ECO:0000313|EMBL:KPP59590.1};
RA   Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT   "The genome of the Asian arowana (Scleropages formosus).";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPP59590.1}.
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DR   EMBL; JARO02011907; KPP59590.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0P7TFM2; -.
DR   STRING; 113540.ENSSFOP00015075100; -.
DR   Proteomes; UP000034805; Unassembled WGS sequence.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR   CDD; cd21070; ELD_TRPML1; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR049134; MCLN_ECD.
DR   InterPro; IPR047316; ML1_ELD.
DR   InterPro; IPR039031; Mucolipin.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   PANTHER; PTHR12127; MUCOLIPIN; 1.
DR   PANTHER; PTHR12127:SF6; MUCOLIPIN-1; 1.
DR   Pfam; PF21381; MCLN_ECD; 1.
DR   Pfam; PF08016; PKD_channel; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        288..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        346..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        417..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        485..506
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          91..273
FT                   /note="Mucolipin extracytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF21381"
FT   DOMAIN          377..512
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KPP59590.1"
SQ   SEQUENCE   569 AA;  64074 MW;  7F67C19C5B85CE56 CRC64;
     NDKLLRSATK YGSSDFRDHN ASDPQLVPAA NLLGAEEAEE ALRRKLKYFF MSPCDKYHAK
     GRKPFKLGLQ ILKIIVVTIQ LVLFGLSNQM VVTFKEENTA SFKNLFLKDY GEGSEDSLAV
     YTQSDVYSHI FYTIEQYLAL PETTVGRYAY VFGVGVNGSA LSLCQQYYKK GHIDPANDTF
     KIDPRVVTDC VGVSPMVEPL AEASADYRNF TLKFHKLINV TIQFQLKAIN VQTILNNEIP
     DCYTFFITIV LDNKAHSGKV KISLDNQASI KECTSPSVSG HAENHARLAF DLFVAFLCLL
     SLVLCGRSIV RGILLQQAGH GAWRFFKTTL DRKVSWADRL EFINGWYILL VVSDILTITG
     SFIKIGIDSK NLSSYDVCGI LLGTSTLLVW VGVIRYLTFF QKYNILIVTL RAAFPNVIRF
     CCCVAVIYLG YCFCGWIVLG PYHVKFRSLS MVSECLFSLI NGDDMFVTFS EMQDSSTLVW
     VFSQVYLYTF ISLFIYMVLS LFIALITGAY ESIKQQTQEP IHITDLHAFI AECTDTPNSG
     KFRGLETSPC SFFCCCDRTT TYEDVLLVN
//