ID A0A0P7TZL8_SCLFO Unreviewed; 558 AA.
AC A0A0P7TZL8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 22-FEB-2023, entry version 34.
DE SubName: Full=Membrane frizzled-related protein-like {ECO:0000313|EMBL:KPP67051.1};
GN ORFNames=Z043_114395 {ECO:0000313|EMBL:KPP67051.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP67051.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP67051.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP67051.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP67051.1}.
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DR EMBL; JARO02005282; KPP67051.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7TZL8; -.
DR STRING; 113540.ENSSFOP00015012385; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07066; CRD_FZ; 1.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF36; MEMBRANE FRIZZLED-RELATED PROTEIN; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00063; FRI; 1.
DR SMART; SM00192; LDLa; 2.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 74..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 115..226
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 274..387
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 435..558
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 32..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 233..245
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 240..258
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 252..267
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 394..406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 401..419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 413..428
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 558 AA; 60000 MW; B1FBA4E688EE67F1 CRC64;
MGEQIAVTVE TPPPDTYKTV FCNPAFEAEN ELEGNKDDIG TGDSGSKQQS PPASDGGRSL
DPTPVGRPWC GCSALVLAAC LLLLIAALGL ALVLIFMRES ITPNCPFSNS PSPECGGILT
DPDGTFSSPN HPGPYPPDSL CLWVIQVRPP ALVQLRVSSL SVEGPSPCLF DWLELREVAE
ETSFITRFCG NVAPPTVNTN SSTVWVTFRS DSSIGGNGFA AQYQAILPQQ KSCSQDEFLC
DDGHCVLPVS VCDGKPDCRD RSDEGNCSHK HKECGGQKTG PEGSLSSPNH PKPYPPLQLC
TWHISVAEGH VIRLSFRNFS LETKETCEFD YVEVHDSADT AGDRVLGRFC GTGLPPELTS
TGPVMTVLFV ADEGVADSGF FASYQAIAVS HRTCSTAQFA CSTGECVNRE LLCDGWSDCA
DSADEQGCAN TTYPSFSSSC EPIQVEMCQG LSYNLTAFPN IWLSIADQRE AAMVLQQHKV
RHSQVLMELA CFQSLRRMVC GMVVPQCSPQ GGVLQPCRSV CIAAQQQCGQ ALDLLSLGWP
SNCHLFPDSQ DLVECSLP
//
