ID A0A0P7U6V0_SCLFO Unreviewed; 1211 AA.
AC A0A0P7U6V0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2-like {ECO:0000313|EMBL:KPP65636.1};
DE Flags: Fragment;
GN ORFNames=Z043_115934 {ECO:0000313|EMBL:KPP65636.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP65636.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP65636.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP65636.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP65636.1}.
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DR EMBL; JARO02006171; KPP65636.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7U6V0; -.
DR STRING; 113540.ENSSFOP00015026067; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04103; Centaurin_gamma; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819:SF3; ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 653..873
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 907..1024
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 1083..1115
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 33..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1151..1166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1211
FT /evidence="ECO:0000313|EMBL:KPP65636.1"
SQ SEQUENCE 1211 AA; 131300 MW; C5D4C27D4943884E CRC64;
MKLEHMSRAE TQHRRTTYLI SLTLVKVEAV GENGAQPTKV TARGRETGQR NTGGDLREDE
KGPPTSARRL QEEDLELKTK ESLRLEREKN RREKNERQQF ITAKNEQPAD DRAQVKLQGL
DAKSGWAEAR GKKVKSEMST EEAAEACRGT LILKPVEVTQ PKSNTPLQVS QRPGALLADP
SGLMSQQEHK DFKRSAIGFS QSLEYTGNKV RTKSEATLMS CPSRISWTGG EGRARSQPGE
STMGAGDSAA CDSPRPERLK TGSTSLPGPF SQASKPPHKG KSRTLDNSDL HSLSEDLRWG
KGVQMTASMG PTLLHSHAQR TSARDRKMLK FISGIFAKST TVPAGTATAP SLYRSVQRES
SEEEVACSYS QEWTLSRSVP ELRLGVMGSL RSNKSALVNR YITGSYLPLE SPEGGRYKKE
VLIDGQSHLL LIREESGPPD AQFSAWVDAV ILVFGLENEN SFHEVYQNYG KLSTYRDITE
IPLIVVATQD KISSTNPRVI DDARVRQICC DLRRCVYYET CATYGLNVNR VFTEAAQKIS
ALKKQNAIQA SCKSLPSSPS HSGGSTPVSG SIPGQASNGG QSSDYSSSLP STPVVSRRNL
QGTLTADGVG IATPGVQRNP SSQRISRFTN SRSNDSEKKG AEGKGEMGSG RSIPIKQSIL
LKKSGNSLNK EWKKKFVTLS SSGILSYHSS VHEYMQNAHG KEIDLLRVTV KVPGKRPPRA
MPAGGPPAGL NGLVKDMSSS EGPGAAPLFP SNLLPVEEGV GREGTISPRG GRGIQRCPSS
LSSKSQSMDS AIEGMNSPPS AKDLVPSSPM VSRSKARRKK SMNQRGDAAI GQAEDEENFD
FVIVSSTGQT WNFEASSLEE RDAWVQAIKI LRKQQEQGKS RVSPKPVEKG REAVTNRTAG
RNSQNEAVAL QAIRNAKGNS FCVDCGAASE LFSVCPLLPF LLLAVMRVAR VRVCAPGSPP
VVHDPTWASL NLGALICIEC SGIHRNLGTH LSRVRSLDLD DWPRELTRVL AAIGNHMANS
IWESCTKGRQ KPSQEATRSS MSASLLSAVT QRDLPRLLLL LAHSNKEEMN TPLPTPPGGA
VQQAHSALHA ACQLGDVVMT QLLVWYGSDV KAKDCQGRTA LAMARCAGSQ ECADILLQHG
CPDEAPPTAP TLGLSRNSST TSLSRTSSRR GRVRLCNFLL LNAVALSVCA NNELEGLDTA
RQRKKDQYQL Q
//
