ID A0A0P7UAW6_SCLFO Unreviewed; 519 AA.
AC A0A0P7UAW6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Putative short-chain dehydrogenase/reductase family 42E member 2 {ECO:0000313|EMBL:KPP64741.1};
DE Flags: Fragment;
GN ORFNames=Z043_116882 {ECO:0000313|EMBL:KPP64741.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP64741.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP64741.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP64741.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP64741.1}.
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DR EMBL; JARO02006812; KPP64741.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7UAW6; -.
DR STRING; 113540.ENSSFOP00015015634; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 119..403
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KPP64741.1"
SQ SEQUENCE 519 AA; 57594 MW; F6138665DF155EE0 CRC64;
CESVLERYLL STAISGSSFS LAVKELVHVT TGRHMNTGNQ NPNMHDNSVA WPADQLTSLC
VPGQNSRPIQ QRTNGHAPWA NGTAHRANST AAGWYQNQDC TMSLLHGIST DWATVGKVLV
TGGAGYFGHR LGKALARAGA SVILLDIVTP RWDIPDGAAF HQNRLSHAVS RGTGANPIDI
RDYDSLYSVC NEVDCIFHTA SYGMSGPEQL NKEQVESVNV GGTSNVINVC LKRRVSRLVY
TSTVNVAFVG LPIEEGDEDS APCLPLGLHT DHYSRTKAIA ERMVLEANGC PLKGGSLLQA
CVLRPSGIYG PEERRHLHRV MVNIERRLFC FSFGNREARM NWVHVDNLVM AHVLAAEGLT
LSKDYVASGQ AYFINDGESV NLFEWLTPLF ERLGYSRPHM HLPVSLVYSA AFLMECLHVI
LRPVADVPLL FTRNEVWNIA VTHTFKIEKA RRDLGFSPRR YNLADSVDQY LKTRSVQPTK
PLLATHRLLM LVVLGVASIL YFCWENFSLQ PRDHTKIYS
//
