ID A0A0P7UD26_SCLFO Unreviewed; 803 AA.
AC A0A0P7UD26;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Leucine-rich repeat-containing protein 8A-like {ECO:0000313|EMBL:KPP72006.1};
DE SubName: Full=Volume-regulated anion channel subunit LRRC8A {ECO:0000313|Ensembl:ENSSFOP00015020187.1};
GN Name=LRRC8A {ECO:0000313|Ensembl:ENSSFOP00015020187.1};
GN ORFNames=Z043_109036 {ECO:0000313|EMBL:KPP72006.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP72006.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP72006.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP72006.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSFOP00015020187.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR EMBL; JARO02002743; KPP72006.1; -; Genomic_DNA.
DR RefSeq; XP_018584271.1; XM_018728755.1.
DR RefSeq; XP_018584272.1; XM_018728756.1.
DR RefSeq; XP_018584273.1; XM_018728757.1.
DR STRING; 113540.ENSSFOP00015020187; -.
DR Ensembl; ENSSFOT00015020419.2; ENSSFOP00015020187.1; ENSSFOG00015012990.2.
DR GeneID; 108920184; -.
DR KEGG; sfm:108920184; -.
DR CTD; 557928; -.
DR GeneTree; ENSGT00940000154043; -.
DR OrthoDB; 55205at2759; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR Proteomes; UP000694397; Chromosome 21.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF3; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00365; LRR_SD22; 3.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 4.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 30..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..333
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
SQ SEQUENCE 803 AA; 93543 MW; 18388D7A59785737 CRC64;
MIPVTELRYF ADTQPAYRIL KPWWDVFTDY ISIVMLMIAV FGGTLQVTQD KMICLPCKWV
VNKTCDSYLS RLYFNATFSS VPLAVEPRGI QYDLDRHQYN YVDAVCYENK LHWFAKYFPY
LVLLHTLVFL ACSNFWFKFP RTSSKLEHFV SILLKCFDSP WTTRALSETV VEERDPKPVL
GKLNGSMDKK ASCASEDVEA SVPMLQRAKT RIEQGIVDHS ETGVLDKKEG EQAKALFEKV
KKFRTHVEEG DIVYRLYIRQ TIIKVIKFIL IICYTGYYVS HIQFSVDCSV DIENLTGYRM
YRCAHPLATL FKILACFYIS LVVVYGLICM YTLCWMLRRS LKKYSFESIR EESSYSDIPD
VKNDFAFMLH MIDQYDPLYS KRFAVFLSEV SENKLRQLNL NNEWSLEKLR QRITRNSQDK
LELHLFMLSG IPDTVFDLLE LEVLKLELIP DVTIPPIIAQ LTSLKEMWLY HTPAKIEAPA
LAFLRENLRS LHIKFTDIKE IPLWIYSLKN LTELHLTGNL SAENNRYIVI DGLRELKRLK
VLRLKSNLTK LPQVVTDVGV HLQKLSINNE GTKLMVLNSL KKMVNLTELE LIRCDLERIP
HSIFSLHNLQ EIDLKDNNLK TIEEIISFQH LHRLVCLKLW YNQIAYVPIQ IGTLTNLERL
YLNRNKIEKI PSQLFFCRKL RFLDLSHNNL TYIPADIGFL SNLQYFAVTA NRIETLPPEL
FLCKKLRTLN LGNNCLQSVP SRFGELTGLV QLELRGNRLE GLPVELGECR LLKRSGLVVE
EDLFNTLPSE VKERLWRADK EQA
//
