ID A0A0P7UG09_SCLFO Unreviewed; 548 AA.
AC A0A0P7UG09;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Early growth response protein {ECO:0000256|RuleBase:RU363046};
GN ORFNames=Z043_112610 {ECO:0000313|EMBL:KPP68690.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP68690.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP68690.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP68690.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional regulator. Recognizes and binds to the DNA
CC sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target
CC genes. Binds double-stranded target DNA, irrespective of the cytosine
CC methylation status. Regulates the transcription of numerous target
CC genes, and thereby plays an important role in regulating the response
CC to growth factors, DNA damage, and ischemia. Plays a role in the
CC regulation of cell survival, proliferation and cell death.
CC {ECO:0000256|RuleBase:RU363046}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU363046}.
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00005682, ECO:0000256|RuleBase:RU363046}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP68690.1}.
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DR EMBL; JARO02004335; KPP68690.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7UG09; -.
DR STRING; 113540.ENSSFOP00015024555; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR InterPro; IPR021839; EGR1_C.
DR InterPro; IPR021849; EGR_N.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR14003:SF23; GENE 12845-RELATED; 1.
DR PANTHER; PTHR14003; TRANSCRIPTIONAL REPRESSOR PROTEIN YY; 1.
DR Pfam; PF11914; DUF3432; 1.
DR Pfam; PF11928; DUF3446; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU363046};
KW DNA-binding {ECO:0000256|RuleBase:RU363046};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU363046};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU363046};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|RuleBase:RU363046};
KW Transcription regulation {ECO:0000256|RuleBase:RU363046};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU363046};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 383..412
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 413..440
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 58579 MW; AD7D820B1479D7E0 CRC64;
MAGKESSSDP ADKPGDHPEC VVGHHQQQQH LHISPLKWAG ASPHLRATAL PSSDLHSSTS
GGRGNPAREM AAAKTEMVLP ALQISEPLNF PHSPMDNYPK LEEMMLLNSA GTPFLTASAP
EGAGFGTGEP GDQYDHLTGD TLPDISLNCE KSLAEQSFPT QRLPPISYTG RFTLEPAANC
SNSLWAEPLF SLVSGLVGMT PPTTSAPASS TAPTSASSSS SSSSSSSSSA STQTSSLSCS
VHHSEPNPIY SAAPTYSSPS PEIFPEQSQS FPSPAVSSSI QYPPPAYPNS KTCTSSFPVP
MIPDYLFPPQ QSEISLVPPD QKPFQSQPGQ QPSLTPLSTI KAFATQTGSQ DLKAVYQSQL
IKPSRMRKYP NRPSKTPPHE RPYACPCRIC MRNFSRSDHL TTHIRTHTGE KPFACEICGR
KFARSDERKR HTKIHLRQKD KKVEKAVAAS APVSVPSPAS SYPSPMTSYP SPVSSYPSPV
PSCYSSPVHT SYPSPSVATT YPSVSSAFQT QVATSFPSSV ATNIYNSPVA TPLSDMQSTL
SPRTIEIC
//
