ID A0A0P7UK90_SCLFO Unreviewed; 2100 AA.
AC A0A0P7UK90;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=Z043_112560 {ECO:0000313|EMBL:KPP68736.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP68736.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP68736.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP68736.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP68736.1}.
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DR EMBL; JARO02004309; KPP68736.1; -; Genomic_DNA.
DR STRING; 113540.ENSSFOP00015044026; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00871; PI4Ka; 1.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 3.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KPP68736.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1535..1746
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1836..2100
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 202..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2100 AA; 236183 MW; BA2D72F77195EF3E CRC64;
MQVQKLQCMC PVDFRGVFQL DERRRDAVIG LGIFLVESDL QHKDVIVPYL LGLLKGLPRV
QWIEDNTQRK GRETLPTAEN FCFCLVTLLS DVVQRDVALR GQVLEAVEDV MQVLLKICQK
PEDHDKEYLC RYTVPCLLGV VRAFGRYSNT SEALLSKLFP RTLPLAAHTG DSSDGAPRRS
FSDFRSILPS PLLTACKGDG ARRKMGSASA SQQASPERGG HPPTSPEDSS TQYFEGSYFL
DGSTVDPDYY FSTISSSFSV SPLFTGGSNR REIDVPLDLL RQLLHMVEQC VGDSFLKTLD
ATVAEFLEEN PGIELYYKTF SDPLYVTMFK MLRDTLYYIK DLPTSFVKEV HDFVLEQFSS
SQSELQKILH DVERLHGDLS PLKLRCQANA ACVDLMVWAV TEEQVIFTLT YCLLFFPQGA
ENLCTKLSEK LQSKTSSKVV MAHMPLLVCC LQGLGCLCER FPVVAHSVTM SLRDFLVLPS
PVLVKLYKYH NQYSAGPGEL KISVTNEHSQ STFSMSNKKS QPSMYEQLRD ISIDNICRQD
AHECLKAGLT MDAVIVEAFL ATLSNRLYIS QENDKEALLI PDHTIRALGH IAVALRDTPR
VMEPILQILQ QKFCQPPSQL DVLIVDQLGC MVITGNQYIY QEVWNLFQQI SVKASSMVYS
TKEYKDHGYR HCSLAVINAL ANIAANLQGE QLVDELLVNL LELFVQLGLE GKRASERASE
KGPALKASSS AGNLGVLIPV IAVLTRRLPP IKEAKPRLQK LFRDFWLYSV VMGFAVEGSG
MVGFVGEVAV RVCTLPPPGL WPQEWYEGVC EIATKSPLLT FPSGEPLRSE LQYNSALKND
TVTPAELNDL RSTIINLLDP PPEVAALVNK LDFAMCTYLL SVYRLEYMRM LRSSDLDRFQ
VMFRYFEDKA IQKDKSGMMQ CVIAVGDKVF EVFLQMMAEK PKTKEHEEEL EHHAQFLLVN
FNHTHKRVRR VADKYLSGLA EAFPHLLWSG RVLKTMLDIL QTLSLSLSAD IHKDQPYYDI
PDTPYRITVP DTQEGREGIV KDFAARCGEI LREAVKWAPS ATKSHLQEYL NKHQNWVSGL
TQHTGLAMAT ESVLHFAGYN RPSATLGATQ LNERPACVKK DYSNFMASLN LRNRYAGEVA
GMIQFSEATR CPSDLSRLVV RRVDEALAGG EPQAFTEAMF KLAALLISSK DSNPQLLHHL
CWAPLKMFTE HGMETAIACW EWLLAARAGI EVPFMREMAS AWQITVEQKM GLFSETQVEA
DPLAASEESQ PMPCPPDVIP HYIWIEFLVQ RFEIAKYCSV DQVEIFASLV QRSLSLSVGG
PSSSLNRHVA AIGSRYRLLT LGLSLLHSDM VTNITIRNVL REKIYSTAFD YFSVHPKFPT
QGDKQLREDI SIMTKFYAGI LSDKKYLAAG QLVTPGETAT NPPQSSLSAG IFGSLIVSST
TPISILNSQD SSLNSLSVMA GADSRTNVDS RQQSAQGWIN TYPLSSGVSS ISKKSGQSKK
SNRGTQLHKY YIKRRTLLLA LLASEIERLT TWYNPLSTQE LAIATEQSVE TSIANWRSKY
INLSEKQWKD NVNLAWSIAP YLAMQLPARF KNAEAIVAEV TRLVRLDPAV VSDVPEAVKF
LVTWHTIDAD SPELSHVLCW APTDPPTGLS YFSSMYPPHP LTAQYGVKVL RSFPPDAILF
YIPQIVQALR YDKMGYVREY ILWAAQKSQL LAHQFIWNMK TNIYLDEEGH QKDPDIGDLL
ERMVEEIIGS LSGPAKDFYQ REFDFFNKIT NVSAIIKPTP KGEERKRACL KALSEIKVQP
GCYLPSNPEA IVLDIDYKSG TPMQSAAKAP YLAKFKVKRC GVSELEREGL RCQSDSLEEG
EESGDGERRI CWQAAIFKVG DDCRQDMLAL QIIGLFKNIF QLVGLDLFVF PYRVVATAPG
CGVIECIPDC KSRDQLGRQT DFGMYDYFRN QYGDESTLAF QKARYNFIRS MAAYSLLLFL
LQIKDRHNGN IMLDSKGHLI HIDFGFMFES SPGGNLGWEP DIKLTDEMVM IMGGKMEATP
FKWFMEMCVR GYLAVRQRFN PTMSEKEAAA FIIKVIQSCF LSSRSKTYDM LQYYQNQIPY
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