ID A0A0P7URL6_SCLFO Unreviewed; 930 AA.
AC A0A0P7URL6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Phospholipase {ECO:0000256|PIRNR:PIRNR009376};
DE EC=3.1.4.4 {ECO:0000256|PIRNR:PIRNR009376};
GN ORFNames=Z043_117005 {ECO:0000313|EMBL:KPP64627.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP64627.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP64627.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP64627.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445,
CC ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4;
CC Evidence={ECO:0000256|PIRNR:PIRNR009376};
CC -!- SIMILARITY: Belongs to the phospholipase D family.
CC {ECO:0000256|ARBA:ARBA00008664, ECO:0000256|PIRNR:PIRNR009376}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP64627.1}.
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DR EMBL; JARO02006893; KPP64627.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7URL6; -.
DR STRING; 113540.ENSSFOP00015045111; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0070290; F:N-acylphosphatidylethanolamine-specific phospholipase D activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0004630; F:phospholipase D activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006654; P:phosphatidic acid biosynthetic process; IEA:InterPro.
DR CDD; cd01254; PH_PLD; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR InterPro; IPR016555; PLipase_D_euk.
DR InterPro; IPR015679; PLipase_D_fam.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR18896:SF121; PHOSPHOLIPASE D2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00614; PLDc; 1.
DR Pfam; PF13091; PLDc_2; 1.
DR Pfam; PF00787; PX; 1.
DR PIRSF; PIRSF009376; Phospholipase_D_euk; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00155; PLDc; 2.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50035; PLD; 2.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR009376};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|PIRNR:PIRNR009376};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|PIRNR:PIRNR009376};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805}.
FT DOMAIN 83..210
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 453..480
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 747..774
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT REGION 492..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 930 AA; 107003 MW; CB7B3286695580F0 CRC64;
MAEADEPVVE ASRAQGLMRR LYSRDDCPLS PDELDALTQN EGEDPRAFCG RPTIVYEHPF
MVVHRLRALK EAGVAPLLKG KPVTCRVDNT ERYTTRSKVR VCTLYTVRLM HGEFTWTVKR
KYKHFQELHR DLFKHKIMIH LLPLGRFATQ RQQLEAMTEE MPSLHDADRV RRASSKPKYL
EEYLNNLLEN CFCRNYHRML EFLEVSPLSF VGDLGPKGLE GFILKRSGGH RIQGLNCFGH
HQFCFRWSRR WLVVKDSFLL YMNHEAEVIS FVLLFDPEFK VLVGRCYTDT KHGVCIQNFT
RTLIIKCSSY RQAQWWSHEI QRLAKPCDFF KVHRFQGFAP PRENTLTKWY VNGSDYFADV
AWALDQAKEE IFITDWWLSP EVHLKRPATS NYWRLDHILN RKAEQGVKVC VLLYKEVELA
LGINSDYSKR VLMNMHPNIK VMRHPDHVSS IVFLWAHHEK MVAIDQSVAF VGGIDLAFGR
WDDSSYRLTD LPAPGAPNHV EAPEVGDAVN LGSGESDSRP QPADARAAEK EDLSGNAQLW
LGKDYSNFIN KDWVQLDRPF EDNINRSQVP RMPWRDLAAV LHGKAARDVA RHFIQRWNFT
KVLRSVDRWS TGTCESSIHK AYVHIIENSQ HYIYIENQFF ISCADGKTVH NEIGDAIVKR
ILRAHSEQQK FRVYVVVPLL PGFEGDISAG GGNAIQAILH FTYRTMCRGE FSILTRLKEQ
MQEQWTQYIS LCGLRTHSQL GQSLVTELIY VHSKMLIADD RRYIIGSANI NDRSMLGSRD
SELAVLVEDE ETVLSCMGGA EYQAGPLTLA LRKECFRVLL GVDSECSADI QDPVSEEFFQ
EVWNKTAASN ARIYETVFHC LPSNSIHSLR ALRELNPGDR LCETEPERAK EELGAVRGLL
VHFPLNFLSE ENLLPPLSSK ERMVPMEVWT
//
