ID A0A0P7V0L5_SCLFO Unreviewed; 518 AA.
AC A0A0P7V0L5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 22-FEB-2023, entry version 18.
DE RecName: Full=Integrator complex subunit 14 {ECO:0000256|ARBA:ARBA00016816};
DE AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000256|ARBA:ARBA00029992};
DE Flags: Fragment;
GN ORFNames=Z043_106340 {ECO:0000313|EMBL:KPP74496.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP74496.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP74496.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP74496.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC in their 3'-box-dependent processing. {ECO:0000256|ARBA:ARBA00003473}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the INTS14 family.
CC {ECO:0000256|ARBA:ARBA00007451}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP74496.1}.
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DR EMBL; JARO02001760; KPP74496.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7V0L5; -.
DR STRING; 113540.ENSSFOP00015068996; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR039841; INTS14.
DR InterPro; IPR045814; IntS14_b-barrel.
DR InterPro; IPR046471; IntS14_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR13532:SF3; INTEGRATOR COMPLEX SUBUNIT 14; 1.
DR PANTHER; PTHR13532; UNCHARACTERIZED; 1.
DR Pfam; PF19435; IntS14_b-barrel; 1.
DR Pfam; PF20504; IntS14_C; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805}.
FT DOMAIN 10..124
FT /note="VWFA"
FT /evidence="ECO:0000259|Pfam:PF13519"
FT DOMAIN 206..353
FT /note="Integrator complex subunit 14 beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF19435"
FT DOMAIN 401..508
FT /note="Integrator complex subunit 14 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20504"
FT REGION 361..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KPP74496.1"
SQ SEQUENCE 518 AA; 57403 MW; F72DB4F56DE8A27C CRC64;
LVSRPPAMPT VVLMDVSLSM TRPVQLDGTE EFQRKNLAVH GLTMLFEHMA TNYRLEFTAL
VAFSSLWELM VPFTRDYNTL QEALNNLEDY DKTCLEPALQ GVSNIVQQEW GSTCPCQVVL
VTDGSLGIGR GSLRHSLSTI KHRSEDKKFP LPFPFPAKLY IMCIANAEEL QNSDTLDNLE
QLLSLNGGEG QIFTVEGPLK LIDQAYTPFH AVLRCGNLSS DVQVFPRPEP VIMDEEVDPA
PRTILTDLEI VGFIEIGDIS SPPVLSRHLV LPIAVNKDVD EMGTGTTDET EEENSANQMA
GKSPNFCVLL HGSLKVEGMV ALVQLGPEWY GMLYSQADSK KKSNLMMSLF EPGPEPLPWL
GKVSQLGPTS DAKENPYGED DSKSPFPLQP KSKRSYAQNV TVWIKPSGLQ TDVQKILRNA
RKLPEKTQTF YKELNRLRKA ALAFGFWDLL KGVADLLERE CTLLPDTAHP DAAFQLSHAA
QQLKLASTGD SQYAAFDHNI TPMLTDFSGS GSSDRDRM
//
