ID A0A0P7V755_SCLFO Unreviewed; 169 AA.
AC A0A0P7V755;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Multifunctional fusion protein {ECO:0000256|RuleBase:RU049442, ECO:0000256|RuleBase:RU364136};
DE Includes:
DE RecName: Full=Fibroblast growth factor 1 {ECO:0000256|RuleBase:RU364136};
DE AltName: Full=Acidic fibroblast growth factor {ECO:0000256|RuleBase:RU364136};
DE AltName: Full=Heparin-binding growth factor 1 {ECO:0000256|RuleBase:RU364136};
DE Includes:
DE RecName: Full=Fibroblast growth factor {ECO:0000256|RuleBase:RU049442};
DE Short=FGF {ECO:0000256|RuleBase:RU049442};
GN ORFNames=Z043_112261 {ECO:0000313|EMBL:KPP69012.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP69012.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP69012.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP69012.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the regulation of cell survival,
CC cell division, angiogenesis, cell differentiation and cell migration.
CC Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and
CC integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1
CC dimerization and activation via sequential autophosphorylation on
CC tyrosine residues which act as docking sites for interacting proteins,
CC leading to the activation of several signaling cascades. Binds to
CC integrins. Its binding to integrins and subsequent ternary complex
CC formation with integrins and FGFR1 are essential for FGF1 signaling.
CC {ECO:0000256|RuleBase:RU364136}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544, ECO:0000256|RuleBase:RU364136}.
CC Secreted {ECO:0000256|RuleBase:RU364136}. Cytoplasm
CC {ECO:0000256|RuleBase:RU364136}. Cytoplasm, cytosol
CC {ECO:0000256|RuleBase:RU364136}. Nucleus
CC {ECO:0000256|RuleBase:RU364136}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000256|ARBA:ARBA00007936, ECO:0000256|RuleBase:RU049442}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP69012.1}.
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DR EMBL; JARO02004164; KPP69012.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7V755; -.
DR STRING; 113540.ENSSFOP00015028805; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR CDD; cd00058; FGF; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1.
DR PANTHER; PTHR11486:SF86; FIBROBLAST GROWTH FACTOR 1; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR PRINTS; PR00262; IL1HBGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 3: Inferred from homology;
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657,
KW ECO:0000256|RuleBase:RU364136}; Cytoplasm {ECO:0000256|RuleBase:RU364136};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU364136};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW ECO:0000256|RuleBase:RU364136};
KW Growth factor {ECO:0000256|RuleBase:RU364136};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674,
KW ECO:0000256|RuleBase:RU364136}; Mitogen {ECO:0000256|RuleBase:RU364136};
KW Nucleus {ECO:0000256|RuleBase:RU364136};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU364136}.
SQ SEQUENCE 169 AA; 19045 MW; 7CB448C9F2730B5F CRC64;
MRRLRSAALR QPHATMTDGE VSLLGAGMGV ALYHHTRPRR LYCLNGGFHL RILADGTVEG
SRDEDDPYNV LRVKAVSIGV VVIEGMEGGC YLAMDQDGQL YGSPTLNDEC YFFEKLEENH
YNTYMSQKYR ERSWYVGIKK NGRPKAGPRT HIGQKAIYFL PRALEGASE
//
