ID   A0A0P7V9R1_SCLFO        Unreviewed;       842 AA.
AC   A0A0P7V9R1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   22-FEB-2023, entry version 13.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=Z043_101495 {ECO:0000313|EMBL:KPP78957.1};
OS   Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX   NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP78957.1, ECO:0000313|Proteomes:UP000034805};
RN   [1] {ECO:0000313|EMBL:KPP78957.1, ECO:0000313|Proteomes:UP000034805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Aro1 {ECO:0000313|EMBL:KPP78957.1};
RA   Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT   "The genome of the Asian arowana (Scleropages formosus).";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPP78957.1}.
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DR   EMBL; JARO02000325; KPP78957.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0P7V9R1; -.
DR   STRING; 113540.ENSSFOP00015062147; -.
DR   Proteomes; UP000034805; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF91; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        404..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        453..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        552..573
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        579..603
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        644..668
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        774..798
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          94..121
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   842 AA;  96062 MW;  B122E782ECE6929F CRC64;
     MGDLFRSEEM TLAQLFMQSE AAYCCVSELG ELGMVQFRDL NPDANVFQRK FVNEVRRCEE
     MDRKLRFVEK EIRKASIPIV DTGENPEVPF PRDMIDLEAT FEKLENELKE INTNQEALKK
     NFLELTELKH ILRRTQQFFN EAELRHHQQM EDPSLLEESS ILMDPNEIGR GAPLRLGFVA
     GVIGRERIPM FERMLWRVCR GNVFLRQADI EDPLEDPGTG DRVYKSVFII FFQGDQLKNR
     VKKICEGFRA SLYPCPETPQ ERKDMASGVN TRIDDLQMVL NQTEDHRQRV LQAAAKTLRV
     WFVKVRKMKA IYHTLNLCNI DVTQKCLIAE VWCPVCDLDS IQFALRRGTE RSGSTVPSIL
     NRMQTKQTPP TYNKTNKFTS GFQNIVDAYG IGTYREMNPA PYTIITFPFL FAVMFGDLGH
     GVVLTCAALY LVLRERQLFA KKIDNEMFSM VFAGRYIILL MGIFSIYTGI IYNDCFSKSL
     NIFGSGWSVK AMFGENGANW TAETLQGNAV LQLDPNIKGV FSGPYPVGID PIWNIATNKL
     TFLNSFKMKM SVILGVIHMM FGVTVGLFNH IYFKKPINIF LGFIPEIVFM GSLFGYLVVL
     IFYKWTTYTA AISRDAPSLL IAFINMFLFN YNDPTNQPLY TGQMAVQCLL VVVAIACVPC
     MLIVKTVVLR HQYLLRKRLG TQNFGGIHVR NGPTDDEAEI IRHDQLSQHT EDENEFNLGD
     VAINQAIHTI EYCLGCISNT ASYLRLWALS LAHAQLSEVL WSMVMHLGLS SRSLAGFIGL
     SIIFFFFATL TVCILIIMEG LSAFLHALRL HWVEFQNKFY AGQGFKFIPF SFDSILDGKL
     DE
//