ID A0A0P7VD00_SCLFO Unreviewed; 1034 AA.
AC A0A0P7VD00;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Rho guanine nucleotide exchange factor 1-like {ECO:0000313|EMBL:KPP73102.1};
DE Flags: Fragment;
GN ORFNames=Z043_107833 {ECO:0000313|EMBL:KPP73102.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP73102.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP73102.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP73102.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP73102.1}.
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DR EMBL; JARO02002273; KPP73102.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7VD00; -.
DR STRING; 113540.ENSSFOP00015034165; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805}.
FT DOMAIN 500..562
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 563..626
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 273..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 956..991
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 324..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..941
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KPP73102.1"
SQ SEQUENCE 1034 AA; 115455 MW; 7D4C610D3CC1E50C CRC64;
RHVYRIRPGV QWHTVQLWSR DGTAALRTHA TRGLFGAQSS GAAMSIIGAE DEDFENDLEP
TVDDQCSHFN SIELVKTRPT HLLVFLQHVM LQFDCAPLLC YLHADLFKNY SAKETKKQFL
DFYNTFLDKG AILRVPVPSH VSYELDRTRP DLISEEVQKR YVQDIQVMVI PEVIMQLEDF
RTKRMMGMTR HESELLEVES HHATERIPTE MKEKAVAETL LDRMADSHSA IFGAVASYMK
HLGVKTKTTD NKKSKGFFRK SLIFTPPNLL LGEKEKVHPE RKLSTPSRSM GSDPAPSTFP
IKKPVSSGAV GAFQVTDGND VSGVSISVTS SPDSSQSETG LTSRSDPPSA SEGGEVSPAE
NAMSSISLEL TASTDIPPEE SQDKDRMSGR LARSESLCVE RRRSQRGGSG RAKQSRSRSD
VDLQAASTAA QPPSPSQPHT PLSDGGASAS NSSLTGSVVG PPPPQEEVDP RLLELEQDPP
NWREQVPSAD FQSLSKKEIK RQEVINELFI TEHAHVRMLS VLQMVFFRPM EHTEIASQPE
LATIFLSLDD IFEMHCVFQT LLEAEGKPQC RRLQLKDIIP TEMQRLTKYP LLLENIAKST
EDPEEREMVQ QAADSCRKIL NHVNEEVKEK ENLRMLKDYQ RRLDTSGLKP SNELHQEYKN
IDLTLRKMIF EGPVTWKVTK EKSIEVQCLL LSDLLVLLQR QDDKMLLKCQ SKNHSGVPEG
KQMLSPIIKL SSAFLREVAT DPKAFYVIFT WDSGAQIYEL VANSAADRKN WTELIKSAVE
ELKLNGGTSL ERRKTAVSVS GIGGVPFSPT TLQPPLSLAE NGSGARNANT DNDKFEAKVE
EPRHTLIDYL SANGFQLLCH GNAPQEKVAS GAVEEVAALK RLFVGSSRQS EVLQDAENHG
DVSKKKDPDI DTQSLAEGDS VDEKTEAESR EEEDGEQKGK EDSSTGTPMV LSKDTMAEVL
SRLQSLEQQI KQLQTRRESE LQKKKSNIEE ENIYEGLNLD DCNSAYHQIQ RSQVQCTYQD
VGNVGDYDVQ LEKP
//
