ID A0A0P7VD44_SCLFO Unreviewed; 556 AA.
AC A0A0P7VD44;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Perforin-1-like {ECO:0000313|EMBL:KPP73157.1};
GN ORFNames=Z043_107780 {ECO:0000313|EMBL:KPP73157.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP73157.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP73157.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP73157.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP73157.1}.
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DR EMBL; JARO02002252; KPP73157.1; -; Genomic_DNA.
DR RefSeq; XP_018613833.1; XM_018758317.1.
DR AlphaFoldDB; A0A0P7VD44; -.
DR GeneID; 108938041; -.
DR KEGG; sfm:108938041; -.
DR CTD; 559384; -.
DR OrthoDB; 4221421at2759; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR PANTHER; PTHR46096:SF1; ZGC:163021 PROTEIN; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 60..405
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 406..524
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 556 AA; 62690 MW; CBC479B1AAB30FD2 CRC64;
MECGPDFNGK IPCSKGRATG IGRQLNAIMT ADRHRCLFLL TVSIVFLSNL HGCSCCRTGT
RAECEKARFV PGYNLAGEGF DVILMQRKGA YVIDVKTFMT ANDTCTLCEN NRFKQVQKLP
VSVTDWRQIT SCSKHLHGEI HHSVHSLVRR SASSIINNWG LSLSLNTMIQ ARVGGSHSEI
AEFAKIQANM DKATFAIHEI TCSYYSYRLV DHPKPSKEFS QSLQRLPAEY NETTESLYSR
LIDTYGTHYI RQVQLGGRIQ QVSAFRTCLA TLAGVSISEM KNCLDIDLKI ALGFVPADAS
FTQKCSDKLR KNMNMGRYQG FMSDKIQVLG GEAQHRHILT YQNPSLAYSN WIGSLNDTPE
IVSYAIVPLH HLVSDPAVKD SLRSALRDYI IGNLVLDLHR AERLSQSCPS SPNLDYNCCP
LRARYGKLVV VVERASNLNS DYFSQTDCYV KVFYNGHYKE TGYILDDNNP RWNTVLTFGT
VELGHPLILE LWDSDTHYDD LIGRCRGYPE KGYHSYICKL DQSVFHFSCY VSCDPHLTGE
RCEEYSPGIY GNPYEL
//
