ID A0A0P7VHB3_SCLFO Unreviewed; 1102 AA.
AC A0A0P7VHB3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Inter-alpha-trypsin inhibitor heavy chain H6-like {ECO:0000313|EMBL:KPP72861.1};
GN ORFNames=Z043_108104 {ECO:0000313|EMBL:KPP72861.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP72861.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP72861.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP72861.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP72861.1}.
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DR EMBL; JARO02002355; KPP72861.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7VHB3; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF155; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H6; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..121
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 254..439
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 588..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1102 AA; 120272 MW; E347854A1DD584A5 CRC64;
MCAVQLKVTE FHVRSSVVSR YARTTVHSSV WNQLPVTKEA VFEVDLPSTA FISNFSITSN
DRLYVAQVQE RATAKKIYDE AKRKGKTAGM VSTKEREVEK FRVSVSVPSG TRMSFTLSYE
ELLQRRLGRY ELMLGLRPGQ PVQNLTLEVT VAERTGLSFF RVLPLRTSRL LSNTVRGGAE
PPPSTVIQQM PNCGHVRYSP TWQQQTSFSP KGLNADFILQ YDVKLTDLIG DVQIYDGYFV
HYFAPRGLPV VPKDVIFVID ISGSMIGTKI MQTKQAMATI LGDLREGDHF NIITFSDKVH
IWKEDRTVRA TRQNVREAQD FVKKITATGW TNINSALLSA AQLVNPTTSS PNRTSGDQRI
PLVIFLTDGE ATAGVTAGEA ILRNARNALG SASLFGLAFG DDADFPLLRR LSLENRGVAR
MVYEDADAAL QLKGFYDEVA SPLLSDIQLS YLDDQAFDVT RALFPNYFQG SELVVAGRVK
PGVRDLKVSL TATDSKQKLK LENDVSTFVP EANGTTSSLG CVGEVQGISN FVRRLWAYFT
IRELLQAKLN SSDPATQRLL GEKATNLSLK YNFVTPVTSL VVVKPDIDET APNSTSGSTS
TTTASTTIST TTTSTTSAPD TFSSMAPQPH TPLLVSKTAS SSIPGTKKPS SSSSPRTSKP
KVDPANKLHS SELHSTSRPV QTIPSGKASV LSSRERTAAT PQSKKIPVQK PASAKTATTP
YSTTAPSSAK TVFTAHPGKA SDSSSEAQND TTPDTTDHHH LHLTTLFSGL LSVPPTIPPV
PATDSGVDIE VATLAAATFA PMPGVTDARK PSEASGLLDV SSAIQVIRKD TYDYQIVHAS
ASSQTAQRLF STSVDGDPHF IVRLPKLKQN LCFTIDGKAD DVLRLLEDPV KGIIVDGRLM
WAPSKHGFES QTRTYFDRLT ISSPGGLVVT VTMDVVMLQG EGQEMLTTNR PGSVVRQGMS
VTVDDHLRCW LELGQGLRFL VLFHHYKHPD YLQKPHLGLY VVDGEGLSIQ TQGLLGAFRP
YRQFQHADVE LIRAKDLQST DAGHLAEAVL KKGATKVPVS LQAKNIKDAP GRRHPDKCWV
VAKGDVEKLL GHPYQSYVVN HF
//
