ID A0A0P7VSK4_SCLFO Unreviewed; 1330 AA.
AC A0A0P7VSK4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 22-FEB-2023, entry version 31.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 1-like {ECO:0000313|EMBL:KPP79484.1};
GN ORFNames=Z043_100938 {ECO:0000313|EMBL:KPP79484.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP79484.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP79484.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP79484.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP79484.1}.
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DR EMBL; JARO02000195; KPP79484.1; -; Genomic_DNA.
DR STRING; 113540.ENSSFOP00015023918; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 2.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF193; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00617; RasGEF; 2.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805}.
FT DOMAIN 172..279
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 390..576
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 606..736
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 783..898
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1115..1330
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 45..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 307..341
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 134..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1330 AA; 151460 MW; 277B22E7A65D6257 CRC64;
MVALYSQANS GRFDFRTCGG GMPKDDIPSA IRLLHAHLWE RIESGTANTG RAHTPHATEM
RLSRGASRDR AASVHAASSG ASTLEARTSC PLFRFTRRIY LYVWHLSGRC RDGSAEEGDL
FLFSGGGARK NKQTNKQTNK EEGNKKQASK MQKGVRLNDG HVTYLGLLAK KDGTRRGYLS
KKSSDNTKWH AKWFALLQNM LFYFESESSS RPAGLYLLEG CACERAPSPK PSLSAKECLE
KQYYFTVSFN HDSQKALELR TEDVKDCDEW VTAITHASYR NLATEHESLM QKYLHLLQIV
DTEKMVAKQL RQQIEDGEIE IERLKSEIAG LLKDNEKIQS NPAAAPSNDD SEIKKIKKVQ
SFLRGWMCRR KWKTIIQDYI RSPHAESMRK RNQVVFSMLE AEAEYVQQLH ILVNNFLRPL
RMAASSKKPS ITHDDVSSIF LNSETIMFLH QIFYQGLKAR IASWPTLVLA DLFDILLPML
NIYQEFVRNH QYSLQILAHC KQNRDFDKLL KQYEAKPDCE ERTLETFLTY PMFQIPRYIL
TLHELLAHTP HEHVERNSLE YAKSKLEELS RIMHDEVSET ENIRKNLATE RMIVEGCEVL
LDTSQTFVRQ GSLIQVPMSE KGKIPRGRLG SLSLKKEGER QCFLFSKHLI ICTRGSGGKL
HLTKNGVVSL IDCTLMEEQE GTDDESKLDK SGQDMEHLDF KIVVEPKDSQ SFTIILVASS
RQEKSAWTSD ISQCIDNIRC NGLMMNAFEE NSKVTVPQMI KSDTSLYCDD VDIRFSKMMN
SCKVLQIRYA SVERLLERLT DLRFLSIDFL NTFLHSYRVF TSADIVLDKL ITIYRKPISA
IPARSLELFF ASSQNNKLLF GEPPKSPGTS RKFSSPPPLS ITKSSSPNRR RKLSLNIPII
TGGKALDLAT LSCSPNGYAS MYSSMSPFSK TTLDISKLYI SSTMSSKIPD ETDAKADRVE
ESSHCKQGQG SAISQRRGSV ISTKAMEMKM KRKHHPLSRP PKFSLFSHNN GMVVSSCREL
DNTRSTLSAA SAFAIATAGA NEGTPTKEKY RRMSLASTGF PTDQRNGDKE FVIRRAATNR
VLNVLRHWVS KHSQDFESNT ELKRKVISFL DEVIHDPELL TQERKAAANI IRTLTQEDPG
DNQISPEEMT QLQSQGGKAE PFECHSALEI AEQLTLLDHL VFKVIPYEEF FGQGWMKNDK
NERTPYIMKT TKHFNDITSS LNRSSIFRLK KTWLKVSKQT KAVIDKLQKL VSSEGRFKNL
REALKNCDPP CVPYLGMYLT DLAFIEEGTP NYTEDNLVNF SKMRMISHII REIRQFQQTA
YKIDYQPKKQ
//
