ID A0A0P7WPU7_SCLFO Unreviewed; 1365 AA.
AC A0A0P7WPU7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Rho GTPase-activating protein 35 {ECO:0000256|ARBA:ARBA00040788};
DE Flags: Fragment;
GN ORFNames=Z043_118299 {ECO:0000313|EMBL:KPP63446.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP63446.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP63446.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP63446.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP63446.1}.
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DR EMBL; JARO02007890; KPP63446.1; -; Genomic_DNA.
DR STRING; 113540.ENSSFOP00015007961; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR Gene3D; 1.10.10.440; FF domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR002713; FF_domain.
DR InterPro; IPR036517; FF_domain_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039007; pG1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR032835; RhoGAP-FF1.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR045786; RhoGAP_pG1_pG2.
DR InterPro; IPR039006; RhoGAP_pG2.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR46005; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR PANTHER; PTHR46005:SF1; RHO GTPASE-ACTIVATING PROTEIN 35; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16512; RhoGAP-FF1; 1.
DR Pfam; PF19518; RhoGAP_pG1_pG2; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00441; FF; 4.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF81698; FF domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51676; FF; 2.
DR PROSITE; PS51852; PG1; 1.
DR PROSITE; PS51853; PG2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 429..483
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 485..550
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 593..773
FT /note="PG1 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51852"
FT DOMAIN 801..971
FT /note="PG2 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51853"
FT DOMAIN 1269..1365
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 996..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1365
FT /evidence="ECO:0000313|EMBL:KPP63446.1"
SQ SEQUENCE 1365 AA; 154646 MW; 114DBB2076430878 CRC64;
MMMAKKQDVR SPTYNLVVVG LSGTEKEKGQ CGVGKSCLCN RFVRPSADDF YLDHTSVLST
SDFGGRVVNN DHFLYWGEAC RTLEEGPECR MHVVEQTEFI DDQTFQPHRS TALQPYIKRA
ASNKLASAEK LMYFCTDQLG LEQDFEQKQM PEGKLLVDGF LLCVDVSRGM NRNFDDQMKF
VTNLHNQLAK TKKPVVLVLT KCDEGVERYI KDCHTFALAK KNLQVVETSA RSNVNVDLAF
ITLVQLIDKS RGKLKIVPYF EALKLQSQQI ASAKDRYEWL ISRIVKNHNE TWLNISRRMQ
TSSEYREYVF LEGTAKAKKL FQQHVFRLKQ EHIERRRKNY LIALPQALNF LIPDLDEVDH
LSWSGVQKVL ENKQEFSDWF VVLDDAPWEE TSHIDNMEDD RIPLDLLETP AAENIYDTHL
EHLRNERKRA EMRQEFKAKL ISSPFITAGK PWEEARSFIM NEDFYQWLQE TEYLDIYNQH
QKEIIDKAKD DFQELLLEYS ELFYELVVDA KPSKEKMGAI QEVLGEEPRF KALQKLQAER
DALVLKHIHF VYHPTKDICP SSPFCMDSKI EQILASRFPT RYPFFDCKAQ SGEVKADRIN
LVILGKDGLA RELANEVRAL CTNDDRYMLD GKMYELVLRP IEGNVRLPVN SFHTATFNPH
GCLCLYNSKE SLSYVVESIE KLRDSTLSRR DNSLSHLPLS LLLVTKRGVG SISDIGGETA
QSLIAQGQQV AGKLQCIFLD PASPGIGCGR NVSEKQLNQV LKCLLDSRRN LNFGNRSPPL
PPLPSGIRDL HHQHSLEADL RIVMCLMCGD TYDVDQLLSP FLLPQHCRPM SSLPSGTSVL
LELAVGGQRQ TIELSLLSYH SSFLLRKSRL VHGYIAVYSA RRKASLETLC AFLCEVQDII
PVQLLAVGEN QTELTDCDVT RERLIQGEEL AHEIEARFNT VVCGPGGVVG GLHRIDMLQP
FLKDVVEKRT IVEATHMYDN VVEACTTNEG IHSPRCGSPS PVTALVDSED DVEPSPPYPT
LRDDNTSNIF KLPDLESSDT FSVISEISSF ESKLNNKVPP QVRPKPTVSF DFRKVNLNPY
IDPAGKRKSL PTAMTWPQGV DGGYDPSDYA EPMDAVCKPR PTDEENIYSV PHDSTQGKII
TIRNANKTHS NGGGNGSDSE AESSSLERRR KLSAMGIKPR LYRDRSKRLG RFSSFRTSFS
IGSDDELGVS LKTKEDEAGA QKADSSLNEE SEDPKKRNIL RSLRRTSKKP RAKPRYSISK
PIESNYFGVP LVNVVSPDRP IPLFIDKCIR YIEATGLSTE GIYRVSGNKA EMESMQRQFD
QDHSLDLVEK DFTVNTVAGA MKSFFSELPE PLVPYSMQIE LVEAY
//
