ID A0A0P7WWW2_9RHOB Unreviewed; 232 AA.
AC A0A0P7WWW2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase {ECO:0000313|EMBL:KPQ05483.1};
DE EC=2.1.1.13 {ECO:0000313|EMBL:KPQ05483.1};
GN Name=metH-5 {ECO:0000313|EMBL:KPQ05483.1};
GN ORFNames=HLUCCA12_15370 {ECO:0000313|EMBL:KPQ05483.1};
OS Rhodobacteraceae bacterium HLUCCA12.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae.
OX NCBI_TaxID=1666916 {ECO:0000313|EMBL:KPQ05483.1, ECO:0000313|Proteomes:UP000050476};
RN [1] {ECO:0000313|EMBL:KPQ05483.1, ECO:0000313|Proteomes:UP000050476}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HLUCCA12 {ECO:0000313|EMBL:KPQ05483.1};
RA Nelson W.C., Romine M.F., Lindemann S.R.;
RT "Identification and resolution of microdiversity through metagenomic
RT sequencing of parallel consortia.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPQ05483.1}.
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DR EMBL; LJSV01000020; KPQ05483.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7WWW2; -.
DR STRING; 1666916.HLUCCA12_15370; -.
DR PATRIC; fig|1666916.3.peg.1163; -.
DR Proteomes; UP000050476; Unassembled WGS sequence.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008705; F:methionine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02070; corrinoid_protein_B12-BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 1.10.1240.10; Methionine synthase domain; 1.
DR InterPro; IPR003759; Cbl-bd_cap.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR036594; Meth_synthase_dom.
DR PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR PANTHER; PTHR45833:SF1; METHIONINE SYNTHASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF02607; B12-binding_2; 1.
DR SMART; SM01018; B12-binding_2; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF47644; Methionine synthase domain; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51337; B12_BINDING_NTER; 1.
PE 4: Predicted;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:KPQ05483.1};
KW Transferase {ECO:0000313|EMBL:KPQ05483.1}.
FT DOMAIN 8..102
FT /note="B12-binding N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51337"
FT DOMAIN 102..232
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 232 AA; 25375 MW; 819197AFE62F3CFF CRC64;
MAEDDEIILS ELDDDELVQQ MMDDLYDGLK EEIEEGVNIL LERGWTPYDV LTKALVAGMT
IVGHDFRDGI LFVPEVLLAA NAMKAGMAIL KPLLVETGAP RMGKMVIGTV KGDIHDIGKN
LVGMMMEGAG FEVVDLGINN PVENYLEALE REDADILGMS ALLTTTMPYM KVVIDTMKEK
GIREDYIVLV GGAPLNEEFG RAIGADAYCR DAAVAVETAK QFVARKHNRL NA
//
