ID A0A0P7XDK5_SCLFO Unreviewed; 1124 AA.
AC A0A0P7XDK5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 08-NOV-2023, entry version 19.
DE SubName: Full=CD109 antigen-like {ECO:0000313|EMBL:KPP73366.1};
DE Flags: Fragment;
GN ORFNames=Z043_107553 {ECO:0000313|EMBL:KPP73366.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP73366.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP73366.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP73366.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP73366.1}.
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DR EMBL; JARO02002171; KPP73366.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7XDK5; -.
DR STRING; 113540.ENSSFOP00015001174; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF162; CD109 ANTIGEN; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT DOMAIN 257..382
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 473..535
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1001..1085
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KPP73366.1"
FT NON_TER 1124
FT /evidence="ECO:0000313|EMBL:KPP73366.1"
SQ SEQUENCE 1124 AA; 125956 MW; E4AD3454EDB12C8F CRC64;
ILSANASHPF MLEVKGYVKE REVLNNRTVL EFRPRRSATF IQTDKSNYKP GQVVKIRVVS
IYPDGKPNKS KVNVVIKDPK GHMIQRWLSL DSFLGVVSKE FQLSENPPLG MWTIEASTIN
VHTEKQFLVD YYGKLKISTY NMKPLTLTDQ MKNVTLTITQ NKYSEAWDYW LLYQNQEFNI
SFSDNQSAVE NRAKSLFPSK NMFTQTISLP VPVDGIVPIQ FQLLDYVQFL SIKAFFENSH
EFLWLSTNYF STSNSYLQLR RASFPQQGSD AHWYGAQEIP AQVKSRGQVV AAGKETSASF
SLNPEDDWTP LASIIVYTIH TTGEVVSDVL QVPISKALKN NVSLSWSQAR AKPAEKVELK
VSVSEPGSLV GVLVVDKAAQ LAKPNNGIDM DEVLEKLMEF STEKVDFRYT EMDDDAFSIF
TKCNLKVLTD TVSVRVLPLY QHMYLGLGNE LATMMREDKQ EQEPQVRRDF PETWLWLDAN
MSNNTNLAIF FQLTVFQNFF ISLNLPAYII RGEQLVLEVN LFNYLDRKLE VTVIVVQNSS
FEFVLEKQVF GSNMRTVFVE RQDSASVLFP IRPKVLGEIS ISVKAVSNIA SDAIIRKVLV
KPEGVEQTFT KTLFLELAPS SNALYQEIMF TFPEDVVEGS ERAHVTVVGY QQELTYQRMD
GSFSAFGNLD SSGSTWLSAF VLRCFLQSRP FITVEQTVLT STANWLVQQQ NHDGSFKEPG
TVIHTELQGG LDGPVSLTAY VLMALLEDPA YTNVYSTQVS GAVTFLENNV TLETCTNYSL
SLVAYALSLA NSSKAKTALS ELVRRADVQD GVMSWRTPGV GLVHHWQARS TDIETAAYVL
LAMFTQGMVV EGLSLMKWLC RQQNHLGGYG STQDTIIALQ ALSCYAALSG ADAIDLRITV
NTTASRNETG FQVDSNNYLL LQSQKVTLFF SLLTKKEALR KMIKILNVFY NLNGQGLSRQ
RRSTPGSEAF SLDIEIMADD ADHLNISACA RLLENQIISQ TGMVLIEVGL LSGFTPRAEG
IETNDLVRKV ETPQGKVVIY LESVNTSEVC VTIPTMRSFK VSSVQDATVL IYDYYDPQRK
ARRTYNSELL RSIPVCSFCG PECRSCRATP VISSGASLTA SQQH
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