ID A0A0P7XS82_SCLFO Unreviewed; 522 AA.
AC A0A0P7XS82;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Prolyl 3-hydroxylase OGFOD1 {ECO:0000256|ARBA:ARBA00016364};
DE AltName: Full=2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00031489};
DE AltName: Full=uS12 prolyl 3-hydroxylase {ECO:0000256|ARBA:ARBA00029938};
DE Flags: Fragment;
GN ORFNames=Z043_100577 {ECO:0000313|EMBL:KPP79815.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP79815.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP79815.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP79815.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 =
CC [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate;
CC Xref=Rhea:RHEA:54156, Rhea:RHEA-COMP:13816, Rhea:RHEA-COMP:13818,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:85428;
CC Evidence={ECO:0000256|ARBA:ARBA00001792};
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC -!- SIMILARITY: Belongs to the TPA1 family.
CC {ECO:0000256|ARBA:ARBA00007443}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP79815.1}.
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DR EMBL; JARO02000124; KPP79815.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7XS82; -.
DR STRING; 113540.ENSSFOP00015021585; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
DR GO; GO:0031543; F:peptidyl-proline dioxygenase activity; IEA:UniProt.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 2.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR019601; Oxoglutarate/Fe-dep_Oase_C.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR039558; TPA1/OFD1_N.
DR PANTHER; PTHR12117; HISTONE ACETYLTRANSFERASE COMPLEX; 1.
DR PANTHER; PTHR12117:SF0; PROLYL 3-HYDROXYLASE OGFOD1; 1.
DR Pfam; PF13661; 2OG-FeII_Oxy_4; 1.
DR Pfam; PF10637; Ofd1_CTDD; 1.
DR SMART; SM00702; P4Hc; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW Vitamin C {ECO:0000256|ARBA:ARBA00022896}.
FT DOMAIN 133..235
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KPP79815.1"
SQ SEQUENCE 522 AA; 60276 MW; 7D591141424A07DB CRC64;
KNDTETVGTG KKKDKREETP KISEITEDTD VRDRVKVAWL KKEHLSHGSI ELDCRPFPHC
VIKNFIRNEG FLENLEKELL DLNFHEKSND LYKFKQSDDL KKRKEAHIAG LRAVLFERFR
LWLSSVFAVE LEPVVDVSCA KYEYTDVLLC HDDELEGRRI AFILYLVRPW ESSDGGTLDL
YSVDGNNQPK DIVKSLVPSW NTLIFFEVSP VSFHQVAEVL SKDKCRLSVS GWFHGRSLER
LPRYIEPAAP RSPHLPRDEE LLLEWINPIY LDVAYQAQVQ EEFEESSEIL LKNFLKEDKF
EQVNEALKQS EIQWVKRGPP NKRSYRWAEQ QGLPPCVSAC WELLSSEAFF LLLSNFTGLK
LHFMAAGDDT DEEEEEKDEE RAAGSTDPEP RAAPERQKSE QEKSAKEPST PLCRGELRCW
GHGDYTLIHD TNVDSMEFAL DLLLYFGCEG WQADFGGFTS YIASGEDEEL LTVSPESNSV
ALVYRDKETL KFVKHVNHRS LELERSSPRG TSFYDFSFVY YE
//
