ID A0A0P7ZIL9_9RHOB Unreviewed; 704 AA.
AC A0A0P7ZIL9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KPP80990.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:KPP80990.1};
GN Name=fadN-2 {ECO:0000313|EMBL:KPP80990.1};
GN ORFNames=HLUCCO07_12360 {ECO:0000313|EMBL:KPP80990.1};
OS Rhodobacteraceae bacterium HLUCCO07.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae.
OX NCBI_TaxID=1666914 {ECO:0000313|EMBL:KPP80990.1, ECO:0000313|Proteomes:UP000050369};
RN [1] {ECO:0000313|EMBL:KPP80990.1, ECO:0000313|Proteomes:UP000050369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HLUCCO07 {ECO:0000313|EMBL:KPP80990.1};
RA Nelson W.C., Romine M.F., Lindemann S.R.;
RT "Identification and resolution of microdiversity through metagenomic
RT sequencing of parallel consortia.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|RuleBase:RU003707}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC hydratase/isomerase family. {ECO:0000256|ARBA:ARBA00008750}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP80990.1}.
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DR EMBL; LJSU01000035; KPP80990.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7ZIL9; -.
DR STRING; 1666914.HLUCCO07_12360; -.
DR PATRIC; fig|1666914.4.peg.518; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000050369; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:KPP80990.1};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 297..473
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 478..572
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 609..693
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 704 AA; 76063 MW; 2B95C1149FAFCDA5 CRC64;
MSDQVTLTRD GDIAVVTVDN PPVNALGAAV RQGLSKAMEE IDADDAIKAA IIIGAGRTFP
AGADIREFGQ PPQPPGLSEV CMRIEDTTKP VIAAIHGTAL GGGLEVSLGA HYRISDPKGR
VGLPEVLIGV LPGAGGTIRL PRIAGIEAAL DIMISGRQVS AQEAKSLGIV DRLADGDLLD
SAKAFARELI AEGAGPRKTS ERSEGLGTDE ENAAAIEAAR KGIVKKAKGL FSPARMVDSV
EYSLNHSLQD ASNYERDCFM ECLETPQQKS LVHAFFAERA SAKVPENGRA DPRPLNKIGV
IGGGTMGAGI TVAALNAGFS VTMVERDEES IARGKQNVEK VYARDVEKGR KTEEQKAAIM
ARYTPSTSYD DLSDADLIIE AVFENMDVKK EVFAALDKVA KPGAVLASNT SYLNIDEIAS
ATSRPEDVIG LHFFSPANIM RLLEIVIPTK ASDDAIATGF DLAKKMKKVP VRAGLCDGFI
GNRILGKYAT AAAYMVEDGA SPYKVDEALV NFGYPMGIHA MADLAGLDIG WSNRKNKAAT
RSNDERYSGT IADRLCENGW FGQKTGKGWY IYKEGDRRGT PNPDAEKIID EARRDLGITP
REFTEEEIIR RYLAAMINEG AKVLEEGIAL KPSDIDVTFL FGYGFPRYRG GPMKYADMYG
LENVLKDLRE FEKEDPKFWK PAQLIIEMVE NGESFDDLNK RAAS
//
