ID A0A0P8A5D9_9EURY Unreviewed; 534 AA.
AC A0A0P8A5D9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN Name=gyrA {ECO:0000313|EMBL:KPQ43351.1};
GN ORFNames=MPEBLZ_02072 {ECO:0000313|EMBL:KPQ43351.1};
OS Candidatus Methanoperedens sp. BLZ1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Candidatus Methanoperedenaceae; Methanoperedens.
OX NCBI_TaxID=1719120 {ECO:0000313|EMBL:KPQ43351.1, ECO:0000313|Proteomes:UP000050360};
RN [1] {ECO:0000313|EMBL:KPQ43351.1, ECO:0000313|Proteomes:UP000050360}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Arshad A., Speth D.R., De Graaf R.M., Op Den Camp H.J., Jetten M.S.,
RA Welte C.U.;
RT "A metagenomics-based metabolic model of nitrate-dependent anaerobic
RT oxidation of methane by Methanoperedens-like archaea.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPQ43351.1}.
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DR EMBL; LKCM01000154; KPQ43351.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P8A5D9; -.
DR PATRIC; fig|1719120.3.peg.2271; -.
DR Proteomes; UP000050360; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 6.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KPQ43351.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..165
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
SQ SEQUENCE 534 AA; 59821 MW; C35814C2E6916A83 CRC64;
MRVVIEISRQ AQANIILNQL YSHTQLETTF GVINLALVDG RPMVLPLKEL IINFISHRKQ
VIIRRSQFEL KKAQARAHIL EGLIIALDHI DEVIKLIRAS QTPDEARDGL MSQFGLSIEQ
AKAILDMRLQ RLTGLEREKI DAEYGELQKT IAWLKELLGS EIKILALIKE ELADIKARFS
DKRRTEIIES TGDRVTEDLI PKEDDVITIT NSGYIKRIAV DSYKQQRRGG KGVMGMETKE
EDFVSDLFIG NTHDYLLFFT DKGKVYWLKV YGIPEAGRQA RGTAIVNLLQ LEQGEKITAY
IPISKFDEKH YLLMVTKKGT AKKTQLTDFA NVRKTGIIAI SLDEGDKLVS VKLTDGTKEM
VIGTKHGKAI RFNENDVRDM GRSAYGVRGV RLVGEDEVVS MAVVEEGATL LTVTENGFGK
RTVFDEYRTS NRGGQGVITI DVNIRNGNVV DIRTVREDDE IMVTTSNGII IRVPASGIRV
QGRNTQGVKI MNVGEKDRVV GVATLAKEEE TAGEEKAVQV TLEEMKEPKE EQKP
//
