ID A0A0P8XJ83_DROAN Unreviewed; 8966 AA.
AC A0A0P8XJ83;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Uncharacterized protein, isoform N {ECO:0000313|EMBL:KPU74936.1};
GN Name=Dana\GF19006 {ECO:0000313|EMBL:KPU74936.1};
GN Synonyms=dana_GLEANR_20542 {ECO:0000313|EMBL:KPU74936.1};
GN ORFNames=GF19006 {ECO:0000313|EMBL:KPU74936.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:KPU74936.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:KPU74936.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR EMBL; CH902646; KPU74936.1; -; Genomic_DNA.
DR RefSeq; XP_014759345.1; XM_014903859.1.
DR STRING; 7217.A0A0P8XJ83; -.
DR EnsemblMetazoa; FBtr0386037; FBpp0345945; FBgn0096018.
DR InParanoid; A0A0P8XJ83; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 39.
DR CDD; cd00096; Ig; 3.
DR CDD; cd05748; Ig_Titin_like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 78.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14340:SF24; -; 1.
DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR Pfam; PF00041; fn3; 39.
DR Pfam; PF07679; I-set; 36.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 39.
DR SMART; SM00409; IG; 37.
DR SMART; SM00408; IGc2; 29.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 21.
DR SUPFAM; SSF48726; Immunoglobulin; 39.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 39.
DR PROSITE; PS50835; IG_LIKE; 27.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 9..102
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 122..212
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 231..324
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 338..429
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 441..536
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 546..638
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 643..731
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1767..1859
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1862..1946
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2140..2237
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2240..2338
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2342..2432
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2440..2535
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2541..2636
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2738..2835
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2841..2936
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2940..3032
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3040..3135
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3141..3236
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3240..3329
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3337..3431
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3438..3533
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3537..3627
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3635..3728
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3734..3829
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3833..3922
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3926..4023
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4029..4124
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4128..4218
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4226..4319
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4325..4424
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4525..4618
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4624..4719
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4723..4814
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4820..4913
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4919..5012
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5016..5106
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5114..5209
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5215..5309
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5411..5504
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5510..5604
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5703..5797
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5803..5898
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5997..6095
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6101..6196
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6200..6291
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6298..6392
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6398..6492
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6498..6593
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6587..6684
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6693..6787
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6793..6889
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6989..7083
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7089..7184
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7190..7285
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7291..7369
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7483..7578
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7584..7679
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7684..7773
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7778..7871
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7876..7969
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 8026..8281
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 8349..8437
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8474..8549
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8665..8753
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8773..8863
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8872..8946
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 835..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1253..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1401..1512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3220..3242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4009..4033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4997..5016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6386..6409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6495..6520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6773..6797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8591..8649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..917
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..951
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1056
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1254..1273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1456..1473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1483..1512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8596..8632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 8055
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 8966 AA; 1004451 MW; 3D83E5DE51D23BC8 CRC64;
MGVAEDFAPS FIKKPQLHQE DDGNRLIFEC QILSSPKPDI EWFRSDNKLV EDERTKFKIQ
PDGNNNYTVV LELDDVVEAD AGLYKVKAKN KSGEVSASIN LNFTQGMFSL HENEGQIDGF
APTFAKKPAI RQEEDGKRLL FECRVNADPI PIIKWVHNGT DVKESSRHKL TIDKDGHSYF
ATLEIMNVTV EDAGKYKVNA KNELGESNAT ISLNFDSDEA PIPESADGIK PTFTERPVIR
QSEDGGNVTF ECRCVGEPMP TVTWSHGETI LSEGNRYKMS LTMDQKLYYM ACLEISCVVS
TDQGEYRALA KNRHGSGVAA INLNFESGSK KIPDGKSPRF PKKPTIRQEE DILIMECILE
AHPMPEIVWY CSDTEIINNQ RTKMTRKVIT KDSYSLTLEI KNPTKDDGGS YRCNAINMYG
ESNANIALNF QGASDVNGFA PSFIEKPRII PNESGTLITM KCKCKAKPEP TVTWYRGQEV
VEKNQKIKIN IIVVAEDTYE LTLEIKDPGA SDGGTYRCNV KNEFGESNAN LNLNIEAEPE
LEGEGPTFIE KPRIVSENNG KLVIMECKVK ADPKPDIIWY RNGMAIQEIN KIKMSMEQRG
DQYYIKLELL DPQLDDSGIY KCNIKNSLGE LNANLTLNIE IVPVIKEKPK IIKIIKKRSV
VIECTVASKF QPKCTWYKEA NVVKESTRHV YLVEKIKDGE FAVKLEINDV EESDKGAYKV
VASNEKGEAV SQVVNLIDIP EEDRKPSKPE ILKKLVDQKV TESKMFELLI KLTQSDRKCK
VEWYKGNTLL RETKDITTTF DGTIARLTFS TAKSEHTSNY KVIVINEVGK DESSCKVTVE
KKDKKKDEKP KNNDASDANK ELKEEENKNK TPEVPEDNLE PASKAEEIKK MKSQESKEKT
KLEKEEDKTK IFETQNKADK PVTKLQPKII TKNTEKEVTN VKTDEGKESN EVSSAKIIPQ
SISKKVKSEI PEVNNQQSDL NKNKKTELSS STDTENEWNE PQAAEEKILK KAERKASIIS
VKEDDSLEVR RQSIINCKEE TSIEDSKIEE VRKSSLVVQE SKTGSRRSSI IEKNSLEQVD
TKKLDANKNP QEIKEEIPKL KPSALRRNSK PIEAQKPSED LPHLRKASIA QPKEESKPEA
PKAKTKPKAK SKPKYEELPE IPDYERPVLE KYEKSEFKPS DFGRDVEIPS KMEKPILDGN
KKEPQPESPK NDLLKKTAII EKTPEEKKEL KIGKGKLAYE DDGQDGVSLK PVIIEPQNDS
TDGNSQESKQ AERTSLLDTI KQRRRSSIRN LMTKEPIQNE SFLGVVLKPV IKDSKEQTLP
QQAKQLTKAN ILEKLSSTKA IKAHISDLKK PEAVATLIDD YEVPVLEKYD PVKLDNSKSE
VPTPGIITPD TKSSVVKVPV EFPKEEKPKM TKIQQPAAGE PPKIEVIREK RPSLAPEPPS
RRGSLIPPAD MGRRPSLIIN DEKKLRPGEV MDTRLLRPGE VGEGQLKQHR PGEMGDNKQR
RRPSIDVRRP SVQDLEDLIN KPSTPLRDVG DGGPPSIVDV QESYSVVEDS TAYLTVGVEG
SPAPTFKFYK GVSEILEGGR YKFLTDGQTN TITLCMRKCK PNDEGKYKIV VSNIHGEDSA
EMQLYVSDSS GMDFRAMLKK RRYQKWDKDE QDPNWGDLKE TEKPLPALKK VERKVESFLS
PLIDQFAKEG KDKKVIFEAR FSKPNCKPKW LFRKDEVFTG SKFKFKQEND TYQLIIMTPK
VEDTGKYTIE IGGVSSTAFL NVEEADPTYT FTKTLKKKLE GFTEHETTLE CAVSSSMANV
HWFKDNTKIE SDDPRYLISK DINGNLKLII KESLIEDSGL YRCQLDKQSD KTECNLRVVE
YPYKFVKVLK SQQCVEKDTV TLACEIDDAR GEVQWFRNDE EIKADKRIQI IKDGRKRKLV
IKDCKVTDAG RFKCTTNADK TEAEIIINYQ NRFNKKLKDT DAVEREKLVL DIELQDQTAP
CNWKFNGDPI VPNERIEIKN LGGGKHQIIF NNLEMSDEGE IECESGQITS KCHLSVRKGE
SRPNIDCPDE FTGPISAPVV IEVPFKVSGT KQSPVEAKLF KDGKPLPVKD VDVCIADDKV
IFKIKKPSRD LSGPYQIKLS NGQGEDSKDV HIICQDVPQP PQDVDITDVY QTSCIVNFKP
PTDDGGTPII KYLIERQDIS KKQGWEPVVE VLPSEPLVKK IDDLVPKKQY RFRLRAVNKI
GPSDPATFKS SILAKDPWDE PGKPQSVDLI DWDKDHADLK WEAPENDGGD LITSYILEYK
EKFSNDWVTS KEVDGQTRAA TVDGLKEGQQ YEFRVRAVNR AGPGEPSDKT KSIIAKCRFV
KPFLVGDGLK NITVKKGQTI RYDIKYDGEP EPTATWLKGH DNIKFDNQRI SLEQLERNSS
ITVKKAVRKD TGRYKLVLSN SSGTIESEAQ VVVLDRPLAP GGPLEPDEIR ANHIKMKWKH
PEDDGGCEIT GYTLERMDEE TGRWIPAGEV GPNENSFDFK GLTPNKKYKF RVKAINKEGE
SEPLETSDAI LAKNPYDPPS PPSQPIIDDY DNKSVSLKWN RPPSDGGRPI THYVVEMKDK
FSPTWSEVAQ TEDPTPKCSV EGLKEKMIYQ FRVRAVNKAG ASEPSQPTDN HLCKHKNLKP
QIDRSTFKRV TIKSGRTHKW SVDVIGEPVP TLCWSWRDDI PLNNGDRIKI ENVDYHTDFA
ITNALRKDSG FYTLKAENCN GIDRETVELV VLGKPSSPKG PLAVGDVSAT GCKLQWKKPD
DDGGVPIKEY VVEKMDTATG KWIRVGRSPG EKEPPSFNVT GLSPGSEYMF RVSAVNEEGE
SEPLTSLVGV VAKDPFDEPN KPGAPEVIDH DNESVSLKWM PPNNDGGAPI QKYIIEKKDK
NKPEWEKAIE VSGDKLEAKV GGLQEYGEYQ FRVIAVNKAG LSPPSDASVP QIVKYKKLKP
RIDRTNLKPL LIRAGKPIKY DINVRGEPAP TITWYQNDLE LKPNELPNNS EIKNIPYNTK
ISILDAVRKN TGTYKIKAVN EHGEDEATVE VNILGPPGKP MGPLAVTDIT KDSCKLKWKK
PNDDGGVPIT AYQVEKFDKK QGRWVPVGRS SGNDTEFDVK GLQEGHEYQF RVRAINEEGE
SEPLETDGSI IAKNPYDAAS KPGTPIIDDY DEHMVKLRWE PPKSDGGVPI VGYIIEKKDK
FSPIWDEVLT TNSPAPEAVV KELTEGNVYQ FRVRAVNKAG ASEPSDATGH HLSKPKNLKP
SINREKMNSI KVRAGQAVKF DIDVKGEPAP SLTWIFKEKE LLHTGKVRLE NEDYNTKLTL
LDTSRKDSGQ YRLRAENING VDEADVEVII LDKPSKPEGP LEVSAVHKEG CKLRWKKPKD
DGGVPLTGYV VEKMDTATGK WVPAGSVDSE KTDIEIKGLD PNHRYQFRVK AINEEGESES
LETDSAITAK NPFDVSAPPG LPELEDWDEN HVKLKWEPPI RDGGSPISCY IVEVMDKDTG
EFVKALETDS PICKGIVKKL DEGQQYKFRV RAVNQAGPSD PSEQTNWHTA KPRYLKPHID
RTNLKPVIVK TGLSISLDII IKGEPAPKVQ WLFNGNPLIN QKDGVQIDNI DYNTKFFVMR
AERSQSGKYT IKAINEVGED EAELEISVLG KPAKPEGPLH VNDVTKHSCK LKWNKPKDDG
GAPIDYYEIE KLDPHTSQWL PCGKSTEPEA KVIGLQEGKQ YKFRVRAVNK EGESEDLETE
KPIIAKNPFD EPDKPGRPDP TNWDKDFVDL AWDPPKNDGG APIQKYIIQM RDKSGRSWVD
AATIAGDKTK GTVTGVQEGH EYEFRVVAVN KAGPSDPSDV SKSVIAKPRH LKPHIDRKNL
QKKIMRNGQL LHMDANVKAE PPAKITWVYN GAEIKNSDKI KIENEDYKTT FVIPKVKRTD
CGIYTVTAKN DSGSDTVQVE LEVLCKPSKP KGPIAVSAVL AESVHLKWDK PEDDGGEPIE
HYIVERMDTE TGRWVPVQTT KTPEADVTGL TEGKEYLFRV KAVNSEGESE PLVSDVPTKA
KNPFDPADTP GKPQITDWAA NFCDLKWRAP EDDGGAPITS YIIEKKDPST GKWQKAFESN
TPDCKARVND LIEGKKYQFR VKAVNKAGQS KPSEPSDQLI AKDRFAPPKI DRTHIKDVTI
KAGQPIRYDI KVSGEPPATK AWLHNKARLN SDDTDYNIDI ESYRTKLAVP FAKRLHSGKY
TLKAENESGR DEASFEVIVL DKPGTPEGPL RVSDVHKEGC MLKWNPPLDD GGLPIEYYIV
EKMDTETGRW LSSGRFKEPL AEVCNLEPGH EYKFRVLAVN TEGESNPLIG EQPIIAKNPF
DEPGKPGIPE ASDWDKNHVD LVWRPPINDG GSPISSYIVE KREKGTDKWI KGAEVTAPEL
GEECRASVNN LDENCEYEFR VKAVNAAGPG EPSDSSKFVI TKPRKLGPKI DRRNIRTYNF
RAGEPIFLDI NISGEPAPDV TWQQNNKSVQ STSEYHIENI PYNTKYINNN PNRKDTGLYK
IIALNLYGQD QVELQINIIS KPGKPEGPLE VSEIYKDGCK LKWKKPKDDG GEPIECYLIE
KFDSDTGIWL PVGKTEVPEY NVDGLVSGNE YQFRVKAINK EGESEPLETF GSIIAKDPFT
VPSKPGVPEP TDWTANRVEL SWLEPANDGG SPITGYLIEV KDKYSPLWEK SLETSSPTPI
ATIPGLIEGN EYQFRVVALN KGGQSEPSDP SKTFIAKPRY LAPKIDRRNL RDVTISSGTA
LKLDANITGE PVPKVEWKLS NYPLQSSKNV TIETPDYYTK LVIRPTQRSD SGEYLVTATN
SSGKDSVLIN VVITDKPTPP KGPLQISDVH KEGCHLKWKR PIDDGGTPIE YFQIDKLDSE
TGCWVPCCRS TEPQVDVSGL TPGNEYRFRV SAVNSEGESL PLLGEDAVVA KNPFDEPGKP
ENLRATDWDK DHIDLAWTPP LADGGSPIIG FIIEKKDKYG KWEKAVEVPA NQYEARVPDL
TEGQAYEFRV SAVNAAGPGE PSDATHSLTA KSRNKPPVID RSNLIEVRIK AGQGFGFDCK
VSGEPAPKTK WLLKNKEIHT KENLKITHID YNTKLKVNGA TRSDSGLYTV EAENENGKDS
ANVKVTVIDK PSPPNGPLKV TDVAAEGCTL HWNPPDDDGG QPIDSYSLEK LDEVTGRWIP
AGETDSPITN IRIKGLTPGH KYKFRVRAKN RQGVSDPLTT PHVIEAKNPY DEPTKPGIPI
ITDFDKDFVD LEWTRPDSDG GSPITGYIIE KRDKYSPNFE QIVEINGDIT NGHVPGLIEG
VKYEFRVRAV NKAGLGTPSD STEPHLARSK NLPPNIDRNF MTDIKIKAGN VFEFNVPVSG
EPIPSKEWSH DDSMVINTDR VKITNYNDRT KLRTIDAKRS DTGSYTLVAR NINGVDKHTV
KLIVLDIPTA PEGPLRHNDV SKSSAMLSWR PPRDDGGSEI THYVVEKMDN EAMRWIPVGE
SSSTEIRADN LIENHEYNFR VRAVNKQGQS QPLVTSQLIT AKDPYSHPDK PGQPIAVDWG
KDYVQLEWTA PKKDNGAPIS SFIVEKRPKF GLWERALMVP SNELTAYIPE LTDGGEYEFR
IIAVNRAGPS DPSDPSTPII CKPRFLAPYF DKNSLNDITV HAGKRLGWNL PIEASPKPSI
KWLHNGKETA STRGESSLFQ NELTFEIASA IRGDEGRYTL ILKNEHGCFD ASAHVTVLDR
PSPPKGPVDI TKITRDGCHL AWNVPEDDGG SPILHYVVEK MDLSRGTWSD AGMSTHPVHD
VSRLVHRKEY LFRVKAVNAV GESEPMEAAN SIIAKNEFDE PDAPGKPNII DWDRDHVDLQ
WAEPKNDGGA PLEEYIVQKK EKGYPYWTNV LHVPPNQNNA KVSELTEGQE YEFRVIAVNQ
AGQSEPSEPS DLIKAKARYL APKILSPLRE IRIKAGLIFH IDIDFIGEPA PEAIWTHNNN
PLISNDKSTI TSIGHHTVVH TVNCQRTNSG IYHLLLRNDS GIDEGSFELI VLDRPGPPDG
PMQFEEITAN SVTVSWKPPK DNGGSEISSY IIEKRDLTHG GGWVPAVNYV NAKYNHAVVP
RLLEGTKYEF RVMAENLQGR SDPLTSDHPI IAKNQYTVPG IPGKPEIADS DKDHISIKWK
QPISNGGNSI IGYDIERRDV NTGRWIKING QPIPITEYQD DRVSTNHQYQ YRVSAINAAG
NSKPSEPSSI FHARPLREKP KLYLDGLVGK RLKVRAGEPV NITIPISGAP TPTIEWKKDS
QNLAEGKRVS SDTNSERSVF RIDDSRRQDS GKYSIIASND FGIDKADIEI IVVDKPTPPE
GPLCYTKTAP DHISLQWNPP KDDGGSEITG YVIEFSEFGT DDWKPVPGYC PKTNYTVKGL
LEGRKYIFRV RAENIYGSSD ALEGNPVISK SPFDPPGPPS QPSITAYSPN SASLEWHPPD
YCGGKPISGY IVERRERGGE WIKCNNYPTP NASYTVPDLR DGVRYEFRVT AVNEAGPGQP
SKPSDSVTAK LQCYCPDPPE PPKPDRISKD SVTLSWRPPR NDGKSKIKGY YVEMRPKNGN
DWKPVNELPI NSTVYVVPHL KEGEEYLFRV IAENDVGRSS PSKPSQPIMI EEQPNKPSME
LGSVRDIVCR AGDDFSIHVP YMAFPKPNAS WYSNDTILDD DNRVHQHLTD DAASIVVKNS
NRCDSGQYRL QLKNPSGFDT ATINVKVLDR PGPPSNLRAD EFSGDSLTLY WNPPKDDGGS
PIQNYIIEKK EAHSPTWNKV SSYCTVPFVR IRNLTINKEY DFRVIAENKY GQSDSANTSE
PIKARHPFDV PNAPGIPRGI DSSEDSITIS WSKPKHDGGS PISGYIIEKR LLSDDKWTKA
VHALCPDLTC KIPSLIENAE YEFRVAAVNA AGQSAFSASS DLIFCRRPPN APKITSDLSI
RDMTVIAGEE FHITVPYNAN PRPTPSWTLN GIDVAPNDRV HFNTDDYISV YYNKFAKRCE
TGAYTITLTN TKGADTASCH ITVVDRPAPP QGPLNAYDIT PDNCTLAWKT PLDDGGSPIT
NYVVEKLDPS GTWVKVSSFV RNTHYDVMGL EPQHKYHFRV KAENQYGLSD PLVLSDPIVA
KHQFTVPDEP GQPKVIDWDS GNVTLIWTRP TSDGGSRIQG YQIEYRDIVN DSSWNTYDFL
IKDTKYQLYN LANGTEYEFR IKAKNAAGLS KPSPPSLRFK LKGKVSAPSP PETPQVTKVG
KNYVDLKWEK PLRDGGSRIT NYVIERRDIG GALWVKCNDF NVLDTEYTVT SLIEMGDYEF
RIFAVNSAGR SEPSLCTMPV KVCEVIGGEK PEWITRLQNR VVPHGKDCTL KCEAIGKPSP
ISRWLRNGKE IQMGVSRFSC DSIDGVYRLH ISNVQAGDEG NYTCEATNSL GFVHTTGFLK
IGSPPIINKC PKELYLPEGD NTKIKIYYSG DQPLSVKITK NNEVISDDND ESHFKFTIFD
EYAALFIRDI VKNDAGLYQI EFTNDSGSAI GQFDVRITGI PSSPTGPMGV SNINKHSCIV
TWRQPAHDGG LRVTHYIVER KDVASPHWIT VSSTCKDTSF NVQGLIENQE YIFRVMAVNE
NGMGPPLEGL NPIRAKAPID PPSPPGIPQI LEIGGDFVHL EWTKPESDGG SHIQGYWIDK
REAGSDTWQR VNVTICSATQ INCPHLIETR QYEFQVFAQN AAGISKASSA SQTVKIVDPK
AASPPFVVKP LRDANCIQNH NAQFSCTISG IPRPTITWYK GAREITNGAR YHIYSEGDNH
FLSINDIFGE DADEYVCRAV NKAGAKSTRA ALVIMTAPKL NVPPRFRDTA YFDKGENVVI
KIPFTGFPKP RINWVKEGEN IESGGHYAVE VKERHAVLII RDGSRLDSGP YRITAENELG
SDTAIVQVQI SDRPDPPRFP LIENIGTDSL SLSWKSPVWD GGSDITNYYV ERREHPLASW
IRVGNTRFTL MAVGGLNAGK EYDFRIFADN VYGRSEPSNT STLIKTKEAI KKKPTERKWE
LDANGKKVRG KADGQIKDYD SYVFDIYSKF VPQPVEISQQ SVYDKYDILE EIGTGAFGVV
HRCRERSTGN IFAAKFIPVS HLIERDLIRR EIDVMNQLHH QKLINLHDAF DDDDEMVLIL
EFLSGGELFE RITVEGYVMT EAEVINYMRQ ICEGLKHMHE RNIIHLDIKP ENIMCQTRSS
TNVKLIDFGL ATRLDPNEVV KITTGTAEFA APEIVNREPV GFYTDMWSTG VLAYVLLSGL
SPFAGDNDVQ TLKNVKACEW DFDEQSFNNI SDDGKDFIRK LLVANKEKRM TAHECLLHPW
LTGDHSNMTQ AITRDRYLAY REKIRRKFED FEKYLLPIGR LSEYSSLRKL LMEKYKIHDT
VFDRRQAAPR FVIRPSSQFC YEGQSVKFYC RCIAIATPTL TWTHNNIELR QSVKFMKRYS
GDDYYFIINR VKLDDRGEYI IRADNHYGSR EEVVFLNVQP LPKEQPRYRT ESTPIRRRDP
LPYTFWQEES ESAPSFTFLL RPRVMQARDT CKLLCCLSGK PVPSVKWYKD GRELSKYEYA
MTHSDGVVTM EIIDCKPSDS GKYICKATNC HGFDETECVV IVEGEWVTPE QAELAHNFLY
SGDRKYIEQP LKPAPPQIVT SRQLTSTSMQ ETSETKNDEN SNQSNLSNKK KYAASSLKAP
GSPSRSRSAT KELILPPDDS LMFKPEFIVP LHDLNIHDGE QLVLSCHVKG DPEPQITWSK
NGKSISSSDI IDLKYRNGVA TLTINEVFPE DEGIFTCTAT NSISAVETKC KLTIKALGKN
ISNLRVASKD NAPKVVSHLE SRYVKDGDAV TLACRIIGAE HFDVVWLHNN KEIKPSKDFQ
YSKEANIYRL QIAEIFPEDG GTYTCEAFND VGESFSSCTI NVSVPGDEPK HPAFVRFPIS
VSIQEGENVI FDCELDSEIL NLIWVKDGKP IDETLSRYSF TKENNIYSFS VSKCNMDDVG
QYQAKAIARK GESICAFSVN IYNSEL
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