ID A0A0P8XMI2_DROAN Unreviewed; 2024 AA.
AC A0A0P8XMI2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Down syndrome cell adhesion molecule, isoform L {ECO:0000313|EMBL:KPU75880.1};
GN Name=Dana\Dscam {ECO:0000313|EMBL:KPU75880.1};
GN Synonyms=Ana Dscam {ECO:0000313|EMBL:KPU75880.1}, Dana\GF12235
GN {ECO:0000313|EMBL:KPU75880.1}, dana_GLEANR_12241
GN {ECO:0000313|EMBL:KPU75880.1}, Dscam {ECO:0000313|EMBL:KPU75880.1};
GN ORFNames=GF12235 {ECO:0000313|EMBL:KPU75880.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:KPU75880.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:KPU75880.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH902619; KPU75880.1; -; Genomic_DNA.
DR RefSeq; XP_014763152.1; XM_014907666.1.
DR SMR; A0A0P8XMI2; -.
DR EnsemblMetazoa; FBtr0391629; FBpp0351065; FBgn0084183.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 6.
DR CDD; cd20957; IgC2_3_Dscam; 1.
DR CDD; cd20955; IgI_1_Dscam; 1.
DR CDD; cd20953; IgI_2_Dscam; 1.
DR CDD; cd20956; IgI_4_Dscam; 1.
DR CDD; cd20958; IgI_5_Dscam; 1.
DR CDD; cd20959; IgI_6_Dscam; 1.
DR CDD; cd20954; IgI_7_Dscam; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR InterPro; IPR021012; Dscam_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF14; DOWN SYNDROME CELL ADHESION MOLECULE 3, ISOFORM E-RELATED; 1.
DR Pfam; PF12355; Dscam_C; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 4.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 10.
DR SMART; SM00408; IGc2; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 10.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1627..1648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..138
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 142..237
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 254..347
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 351..430
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 437..531
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 536..622
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 627..718
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 723..815
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 820..912
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 921..1015
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1020..1124
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1125..1221
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1225..1318
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1320..1402
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1410..1503
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1507..1602
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1112..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1696..1727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1801..1854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1870..2024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1817..1844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1956..1973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1983..2000
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2003..2017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2024 AA; 223337 MW; 31B64FAA0A04575F CRC64;
MAYNMNIVME RLKWLMLYAA VGLIVCGSQI LAASPPDADQ KGPVFLKEPT NRIDFSNSTG
AEIECKASGN PMPEIIWIRS DGTAVGDVPG LRQISSDGKL VFPPFRAEDY RQEVHAQVYA
CLARNQFGSI ISRDVHVRAV VPQSYTVNVM DESILRGNSA ILKCHIPSFV ADFIVVDSWV
EDEERVIYPQ EDIAASDGKY LVLPSGELHI REVGPEDGYK SYQCRTKHRL TGETRLSATK
GRLVITEPVG GKAPTLLSND IKRSWIERMQ ATNLAIFCPA QAFPVPVYRW YKFIEGTTRK
QAVVLNDRVK QVSGTLIIKD AVVDDSGKYL CVVNNSVGGE SVETVLTVTA PLSAKIDPPT
QTVDFGRPAV FTCQYTGNPI KTVSWMKDGK AIGHSEPVLR IESVKKEDKG MYQCFVRNDQ
ESAEASAELK LGGRFDPPVI RQAFQEETME PGPSVFLKCV AGGNPTPEIS WELDGKKIAN
NDRYQVGQYV TVNGDVVSYL NITSVHANDG GLYKCQAKSK VGVADHSAKL NVYGLPYIRQ
MEKKAIVAGE TLIVTCPVAG YPIDSIVWER DNRALPINRK QKVFPNGTLI IENVERNSDQ
ATYTCVAKNQ EGYSARGSLE VQVMVLPRII PFAFEEGPAQ VGQYLTLHCS VPGGDLPLTI
EWTLDGQEIP EDSGISTARV GRRGSVLTIE AVEASHAGNF TCHAHNSAGH QQFTTPLNVY
VPPRWILEPT DKAFAQGSDA KVECKADGFP KPQVTWKKAV GDTPGEYKDL KKNDNIRVEE
GTLHIDNIQK TNEGYYLCEA INGIGSGLSA VIMISVQAPP EFTEKLRNQT ARRGEPAVLQ
CEAKGEKPIG ILWNMNNMRL DPKNDNRYTI REEILSTGVM SSLSIKRTER SDSALFTCVA
TNAFGSDDAS INMIVQEVPE MPYALKVLDK SGRSVQLSWA QPYDGNSPLD RYIIEFKRSR
ASWSEIDRVI VPGHTTEAQV QKLSPATTYN IRIVAENAIG TSQSSEAVTI ITAEEAPSGK
PQNIKVEPVN QTTMRVTWKP PPRNEWNGEI LGYYVGYKLS NTNSSYVFET INFITEEGKE
HNLELQNLRV YTQYSVVIQA FNKIGAGPLS EEEKQFTAEG TPSQPPSDTA CTTLTSQTIR
VSWVSPPLES ANGVIKTYKV VYAPSDEWYD ETKRHYKKTA SSDTVLHGLK KYTNYTMQVL
ATTAGGDGVR SVPIHCQTEP DVPEAPTDVK ALVMGNAAIL VSWRSPAQPN GIITQYTVYS
KAEGAETETK TQKVPHYQMS FEATELEKNK PYEFWVTAST TIGEGQQSKS IVAMPSDQVP
AKIASFDDTF NATFKEDAKM PCLAVGAPQP EITWKIKGVE FSANDRMRVL PDGSLLIKSV
NRQDAGDYSC HAENSIAKDS ITHKLIVLAP PQSPHVTLSA TTTDALTVKL KPHEGDTAPL
HGYTLHYKPE FGEWETAEVS VDSQKHNIEN LLCGSRYQVY ATGFNNIGAG EASDILNTRT
KGQKPKLPEK PRFIEVSSNS VSLHFKAWKD GGCPMSHFVV ESKKRDQIEW NQISNNVKPD
NNYVVLDLEP ATWYNLRITA HNSAGFTVAE YDFATLTVTG GTIAPSRDLP ELSAEDTIRI
ILSNLNLVVP VVAALLVIII AIIVICILRS KGNHHKDDVV YNQTMGPGAT LDKRRPDLRD
ELGYIAPPNR KLPPVPGSNY NTCDRIKRGR GGLRSNHSTW DPRRNPNLYE ELKAPPVPMH
GNHYGHAHGN VECHYRHPGM EDEICPYATF HLLGFREEMD PTKAMNFQTF PHQNGHAGPV
PGHAGTMLPP GHPGHVHSRS GSQSMPRANR YQRKNSQGGQ SSIYTPAPEY DDPANCAEED
QYRRYTRVNS QGGSLYSGPG PEYDDPANCA PEEDQYGSQY GGPYGQPYDH YGSRGSMGRR
SIGSARNPGN GSPEPPPPPP RNHDMSNSSF NDSKESNEIS EAECDRDHGP RGNYGAVKRS
PQPKDQRTTE EMRKLIERNE AGPKQLQLQQ TNGAGFTAYD TMAV
//
