ID A0A0P8XMK8_DROAN Unreviewed; 2036 AA.
AC A0A0P8XMK8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Down syndrome cell adhesion molecule, isoform D {ECO:0000313|EMBL:KPU75872.1};
GN Name=Dana\Dscam {ECO:0000313|EMBL:KPU75872.1};
GN Synonyms=Ana Dscam {ECO:0000313|EMBL:KPU75872.1}, Dana\GF12235
GN {ECO:0000313|EMBL:KPU75872.1}, dana_GLEANR_12241
GN {ECO:0000313|EMBL:KPU75872.1}, Dscam {ECO:0000313|EMBL:KPU75872.1};
GN ORFNames=GF12235 {ECO:0000313|EMBL:KPU75872.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:KPU75872.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:KPU75872.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH902619; KPU75872.1; -; Genomic_DNA.
DR RefSeq; XP_014763144.1; XM_014907658.1.
DR SMR; A0A0P8XMK8; -.
DR EnsemblMetazoa; FBtr0382365; FBpp0342587; FBgn0084183.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 6.
DR CDD; cd20957; IgC2_3_Dscam; 1.
DR CDD; cd20955; IgI_1_Dscam; 1.
DR CDD; cd20953; IgI_2_Dscam; 1.
DR CDD; cd20956; IgI_4_Dscam; 1.
DR CDD; cd20958; IgI_5_Dscam; 1.
DR CDD; cd20959; IgI_6_Dscam; 1.
DR CDD; cd20954; IgI_7_Dscam; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR InterPro; IPR021012; Dscam_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF14; DOWN SYNDROME CELL ADHESION MOLECULE 3, ISOFORM E-RELATED; 1.
DR Pfam; PF12355; Dscam_C; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 4.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 10.
DR SMART; SM00408; IGc2; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 9.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1630..1652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..138
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 251..344
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 348..427
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 434..528
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 533..619
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 624..715
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 720..812
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 817..909
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 918..1012
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1017..1121
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1122..1218
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1222..1315
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1317..1399
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1407..1500
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1504..1599
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1109..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1718..1739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1813..1866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1882..2036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1829..1856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1968..1985
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1995..2012
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2015..2029
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2036 AA; 224892 MW; 62C892ED67276D05 CRC64;
MAYNMNIVME RLKWLMLYAA VGLIVCGSQI LAASPPDADQ KGPVFLKEPT NRIDFSNSTG
AEIECKASGN PMPEIIWIRS DGTAVGDVPG LRQISSDGKL VFPPFRAEDY RQEVHAQVYA
CLARNQFGSI ISRDVHVRAV VNQFYEAEIM TEYVIRGNAA VLKCSIPSFV ADFVRVESWI
DDEGNVLTFS DNYDGKYLVL PSGELHIREV GPEDGYKSYQ CRTKHRLTGE TRLSATKGRL
VITEPVGGKA PTLLSNDIKR SWIERMQATN LAIFCPAQAF PVPVYRWYKF IEGTTRKQAV
VLNDRVKQVS GTLIIKDAVV DDSGKYLCVV NNSVGGESVE TVLTVTAPLS AKIDPPTQTV
DFGRPAVFTC QYTGNPIKTV SWMKDGKAIG HSEPVLRIES VKKEDKGMYQ CFVRNDQESA
EASAELKLGG RFDPPVIRQA FQEETMEPGP SVFLKCVAGG NPTPEISWEL DGKKIANNDR
YQVGQYVTVN GDVVSYLNIT SVHANDGGLY KCQAKSKVGV ADHSAKLNVY GLPYIRQMEK
KAIVAGETLI VTCPVAGYPI DSIVWERDNR ALPINRKQKV FPNGTLIIEN VERNSDQATY
TCVAKNQEGY SARGSLEVQV MVLPRIIPFA FEEGPAQVGQ YLTLHCSVPG GDLPLTIEWT
LDGQEIPEDS GISTARVGRR GSVLTIEAVE ASHAGNFTCH AHNSAGHQQF TTPLNVYVPP
RWILEPTDKA FAQGSDAKVE CKADGFPKPQ VTWKKAVGDT PGEYKDLKKN DNIRVEEGTL
HIDNIQKTNE GYYLCEAING IGSGLSAVIM ISVQAPPEFT EKLRNQTARR GEPAVLQCEA
KGEKPIGILW NMNNMRLDPK NDNRYTIREE ILSTGVMSSL SIKRTERSDS ALFTCVATNA
FGSDDASINM IVQEVPEMPY ALKVLDKSGR SVQLSWAQPY DGNSPLDRYI IEFKRSRASW
SEIDRVIVPG HTTEAQVQKL SPATTYNIRI VAENAIGTSQ SSEAVTIITA EEAPSGKPQN
IKVEPVNQTT MRVTWKPPPR NEWNGEILGY YVGYKLSNTN SSYVFETINF ITEEGKEHNL
ELQNLRVYTQ YSVVIQAFNK IGAGPLSEEE KQFTAEGTPS QPPSDTACTT LTSQTIRVSW
VSPPLESANG VIKTYKVVYA PSDEWYDETK RHYKKTASSD TVLHGLKKYT NYTMQVLATT
AGGDGVRSVP IHCQTEPDVP EAPTDVKALV MGNAAILVSW RSPAQPNGII TQYTVYSKAE
GAETETKTQK VPHYQMSFEA TELEKNKPYE FWVTASTTIG EGQQSKSIVA MPSDQVPAKI
ASFDDTFNAT FKEDAKMPCL AVGAPQPEIT WKIKGVEFSA NDRMRVLPDG SLLIKSVNRQ
DAGDYSCHAE NSIAKDSITH KLIVLAPPQS PHVTLSATTT DALTVKLKPH EGDTAPLHGY
TLHYKPEFGE WETAEVSVDS QKHNIENLLC GSRYQVYATG FNNIGAGEAS DILNTRTKGQ
KPKLPEKPRF IEVSSNSVSL HFKAWKDGGC PMSHFVVESK KRDQIEWNQI SNNVKPDNNY
VVLDLEPATW YNLRITAHNS AGFTVAEYDF ATLTVTGGTI APLDDGTGHG NVHTRIRLPA
WMPEWLDLNF MVPLIATVVV VAVGICVVCV ALSRRRADDM RGGQKDVYYD VVYNQTMGPG
ATLDKRRPDL RDELGYIAPP NRKLPPVPGS NYNTCDRIKR GRGGLRSNHS TWDPRRNPNL
YEELKAPPVP MHGNHYGHAH GNVECHYRHP GMEDEICPYA TFHLLGFREE MDPTKAMNFQ
TFPHQNGHAG PVPGHAGTML PPGHPGHVHS RSGSQSMPRA NRYQRKNSQG GQSSIYTPAP
EYDDPANCAE EDQYRRYTRV NSQGGSLYSG PGPEYDDPAN CAPEEDQYGS QYGGPYGQPY
DHYGSRGSMG RRSIGSARNP GNGSPEPPPP PPRNHDMSNS SFNDSKESNE ISEAECDRDH
GPRGNYGAVK RSPQPKDQRT TEEMRKLIER NEAGPKQLQL QQTNGAGFTA YDTMAV
//