ID A0A0P8Y9Q6_DROAN Unreviewed; 2048 AA.
AC A0A0P8Y9Q6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Down syndrome cell adhesion molecule, isoform N {ECO:0000313|EMBL:KPU75882.1};
GN Name=Dana\Dscam {ECO:0000313|EMBL:KPU75882.1};
GN Synonyms=Ana Dscam {ECO:0000313|EMBL:KPU75882.1}, Dana\GF12235
GN {ECO:0000313|EMBL:KPU75882.1}, dana_GLEANR_12241
GN {ECO:0000313|EMBL:KPU75882.1}, Dscam {ECO:0000313|EMBL:KPU75882.1};
GN ORFNames=GF12235 {ECO:0000313|EMBL:KPU75882.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:KPU75882.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:KPU75882.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH902619; KPU75882.1; -; Genomic_DNA.
DR RefSeq; XP_014763154.1; XM_014907668.1.
DR SMR; A0A0P8Y9Q6; -.
DR STRING; 7217.A0A0P8Y9Q6; -.
DR EnsemblMetazoa; FBtr0392262; FBpp0351648; FBgn0084183.
DR InParanoid; A0A0P8Y9Q6; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 6.
DR CDD; cd20957; IgC2_3_Dscam; 1.
DR CDD; cd20955; IgI_1_Dscam; 1.
DR CDD; cd20953; IgI_2_Dscam; 1.
DR CDD; cd20956; IgI_4_Dscam; 1.
DR CDD; cd20958; IgI_5_Dscam; 1.
DR CDD; cd20954; IgI_7_Dscam; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR InterPro; IPR021012; Dscam_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF14; DOWN SYNDROME CELL ADHESION MOLECULE 3, ISOFORM E-RELATED; 1.
DR Pfam; PF12355; Dscam_C; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 4.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 10.
DR SMART; SM00408; IGc2; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 10.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1634..1656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..138
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 142..237
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 254..347
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 351..430
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 437..531
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 536..622
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 627..721
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 724..816
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 821..913
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 922..1016
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1021..1125
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1126..1222
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1226..1319
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1321..1403
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1411..1504
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1508..1603
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1113..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1723..1743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1819..1870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1886..2048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1833..1860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1972..2021
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2024..2041
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2048 AA; 226224 MW; C2DEB7806950705E CRC64;
MAYNMNIVME RLKWLMLYAA VGLIVCGSQI LAASPPDADQ KGPVFLKEPT NRIDFSNSTG
AEIECKASGN PMPEIIWIRS DGTAVGDVPG LRQISSDGKL VFPPFRAEDY RQEVHAQVYA
CLARNQFGSI ISRDVHVRAV VPQSYTVNVM DESILRGNSA ILKCHIPSFV ADFIVVDSWV
EDEERVIYPQ EDIAASDGKY LVLPSGELHI REVGPEDGYK SYQCRTKHRL TGETRLSATK
GRLVITEPVG GKAPTLLSND IKRSWIERMQ ATNLAIFCPA QAFPVPVYRW YKFIEGTTRK
QAVVLNDRVK QVSGTLIIKD AVVDDSGKYL CVVNNSVGGE SVETVLTVTA PLSAKIDPPT
QTVDFGRPAV FTCQYTGNPI KTVSWMKDGK AIGHSEPVLR IESVKKEDKG MYQCFVRNDQ
ESAEASAELK LGGRFDPPVI RQAFQEETME PGPSVFLKCV AGGNPTPEIS WELDGKKIAN
NDRYQVGQYV TVNGDVVSYL NITSVHANDG GLYKCQAKSK VGVADHSAKL NVYGLPYIRQ
MEKKAIVAGE TLIVTCPVAG YPIDSIVWER DNRALPINRK QKVFPNGTLI IENVERNSDQ
ATYTCVAKNQ EGYSARGSLE VQVMVPPHVL PFSFGSEVFN MGDVLSINCV VLKGDLPLSI
HWSLNGAPIK TGVDGFMVVQ MNSRTSYLSV DTLEAKHRGS YSCVAQNLAG KAIYSAELQV
NVPPRWILEP TDKAFAQGSD AKVECKADGF PKPQVTWKKA VGDTPGEYKD LKKNDNIRVE
EGTLHIDNIQ KTNEGYYLCE AINGIGSGLS AVIMISVQAP PEFTEKLRNQ TARRGEPAVL
QCEAKGEKPI GILWNMNNMR LDPKNDNRYT IREEILSTGV MSSLSIKRTE RSDSALFTCV
ATNAFGSDDA SINMIVQEVP EMPYALKVLD KSGRSVQLSW AQPYDGNSPL DRYIIEFKRS
RASWSEIDRV IVPGHTTEAQ VQKLSPATTY NIRIVAENAI GTSQSSEAVT IITAEEAPSG
KPQNIKVEPV NQTTMRVTWK PPPRNEWNGE ILGYYVGYKL SNTNSSYVFE TINFITEEGK
EHNLELQNLR VYTQYSVVIQ AFNKIGAGPL SEEEKQFTAE GTPSQPPSDT ACTTLTSQTI
RVSWVSPPLE SANGVIKTYK VVYAPSDEWY DETKRHYKKT ASSDTVLHGL KKYTNYTMQV
LATTAGGDGV RSVPIHCQTE PDVPEAPTDV KALVMGNAAI LVSWRSPAQP NGIITQYTVY
SKAEGAETET KTQKVPHYQM SFEATELEKN KPYEFWVTAS TTIGEGQQSK SIVAMPSDQV
PAKIASFDDT FNATFKEDAK MPCLAVGAPQ PEITWKIKGV EFSANDRMRV LPDGSLLIKS
VNRQDAGDYS CHAENSIAKD SITHKLIVLA PPQSPHVTLS ATTTDALTVK LKPHEGDTAP
LHGYTLHYKP EFGEWETAEV SVDSQKHNIE NLLCGSRYQV YATGFNNIGA GEASDILNTR
TKGQKPKLPE KPRFIEVSSN SVSLHFKAWK DGGCPMSHFV VESKKRDQIE WNQISNNVKP
DNNYVVLDLE PATWYNLRIT AHNSAGFTVA EYDFATLTVT GGTIAPLDDG TGHGNVHTRI
RLPAWMPEWL DLNFMVPLIA TVVVVAVGIC VVCVALSRRR ADDMRGGQKD VYYDVVYNQT
MGPGATLDKR RPDLRDELGY IAPPNRKLPP VPGSNYNTCD RIKRGRGGLR SNHSTWDPRR
NPNLYEELKA PPVPMHGNHY GHAHGNVECH YRHPGMEDEI CPYATFHLLG FREEMDPTKA
MNFQTFPHQN GHAGPVPGHA GTMLPPGHPG HVHSRSGSQS MPRANRYQRK NSQGGQSSIY
TPAPEYDDPA NCAEEDQYRR YTRVNSQGGS LYSGPGPEYD DPANCAPEED QYGSQYGGPY
GQPYDHYGSR GSMGRRSIGS ARNPGNGSPE PPPPPPRNHD MSNSSFNDSK ESNEISEAEC
DRDHGPRGNY GEDTEAVKRS PQPKDQRTTE EMRKLIESRR QLNEAGPKQL QLQQTNGAGF
TAYDTMAV
//