ID A0A0P9EXW1_9BACL Unreviewed; 693 AA.
AC A0A0P9EXW1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|PIRNR:PIRNR001084};
DE Short=Beta-gal {ECO:0000256|PIRNR:PIRNR001084};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|PIRNR:PIRNR001084};
GN ORFNames=AN477_09620 {ECO:0000313|EMBL:KPV43967.1};
OS Alicyclobacillus ferrooxydans.
OC Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC Alicyclobacillus.
OX NCBI_TaxID=471514 {ECO:0000313|EMBL:KPV43967.1, ECO:0000313|Proteomes:UP000050482};
RN [1] {ECO:0000313|EMBL:KPV43967.1, ECO:0000313|Proteomes:UP000050482}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TC-34 {ECO:0000313|EMBL:KPV43967.1,
RC ECO:0000313|Proteomes:UP000050482};
RA Hemp J.;
RT "Draft genome sequence of Alicyclobacillus ferrooxydans DSM 22381.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412,
CC ECO:0000256|PIRNR:PIRNR001084};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 42 family.
CC {ECO:0000256|ARBA:ARBA00005940, ECO:0000256|PIRNR:PIRNR001084}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPV43967.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LJCO01000042; KPV43967.1; -; Genomic_DNA.
DR RefSeq; WP_054968941.1; NZ_LJCO01000042.1.
DR AlphaFoldDB; A0A0P9EXW1; -.
DR STRING; 471514.AN477_09620; -.
DR PATRIC; fig|471514.4.peg.500; -.
DR OrthoDB; 9800974at2; -.
DR Proteomes; UP000050482; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:InterPro.
DR CDD; cd03143; A4_beta-galactosidase_middle_domain; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR013739; Beta_galactosidase_C.
DR InterPro; IPR013738; Beta_galactosidase_Trimer.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR003476; Glyco_hydro_42.
DR InterPro; IPR013529; Glyco_hydro_42_N.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR36447; BETA-GALACTOSIDASE GANA; 1.
DR PANTHER; PTHR36447:SF2; BETA-GALACTOSIDASE YESZ; 1.
DR Pfam; PF02449; Glyco_hydro_42; 1.
DR Pfam; PF08533; Glyco_hydro_42C; 1.
DR Pfam; PF08532; Glyco_hydro_42M; 1.
DR PIRSF; PIRSF001084; B-galactosidase; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|PIRNR:PIRNR001084};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR001084};
KW Reference proteome {ECO:0000313|Proteomes:UP000050482}.
FT DOMAIN 15..387
FT /note="Glycoside hydrolase family 42 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02449"
FT DOMAIN 401..608
FT /note="Beta-galactosidase trimerisation"
FT /evidence="ECO:0000259|Pfam:PF08532"
FT DOMAIN 637..681
FT /note="Beta-galactosidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08533"
FT ACT_SITE 151
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-1"
FT ACT_SITE 310
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-1"
FT BINDING 112
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-2"
FT BINDING 150
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-2"
FT BINDING 318
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-2"
SQ SEQUENCE 693 AA; 79039 MW; D4D9AA237C49FA29 CRC64;
MTKTLHAKSL KVGVCYYPEH WSSDMWDSDL EMMRHMGITM VRVGEFAWSI FEPKDGEFSF
QLFDEFIERA GQFGIGVILG TPTATPPAWL TYKYPEVLNV SLDGIQFQHG LRRHYNYNSP
VYQQYCRRIV EKMAKHYGEN THVIGWQIDN ELNCEIDVFY SERDHEAFRQ WLTVKYGTLD
RLNHAWGTVV WSQTYTAWEQ VHLTRPNPSH SVNPHQALDE KRFISNSVMR FVENQTEVIR
QYAPHQFITT NGIFGHLDTH ELTERYLDFI SYDSYPNFGM LADDESLRDR EWSFNLSVAR
SVSPNFCVME QQAGPGGWVN RIEQPTPLPG QLRLWAFQSL AHGADAIVFF RWRTAPFGTE
IYWHGIFDYD NQPNRRVAEI GQTINEVSLL ADKLAGSLVQ ADVALLRDYN NDWDGEVDTW
HGPYTKKSVK EWFRGLQTSH VPCDVLNLSE TTQLADLRRY KVLVYPHPVV LSERVTELLE
QFVSAGGILI TGCRAGLKDV NGHCRQVSMP GPLKNLFGVQ VSDFTRIQGA YEVPNLVWNG
DESSSGCIHA VDFNEVLQPT SEDCTVLATY DRNYYSGTPA LVQNSFGKGT TYYYGSVFTR
ELAKKLIELT GLVDTENKLV STTEEVELEI RRNPLTGDRY VFLLNYSGQP QAVHLHHGCR
NALNGELIEG DLVLDGYDVL VCEVPDGGAT ARG
//