ID A0A0Q0HEK8_9GAMM Unreviewed; 293 AA.
AC A0A0Q0HEK8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=2-(Hydroxymethyl)glutarate dehydrogenase {ECO:0000313|EMBL:KPZ52626.1};
DE EC=1.1.1.291 {ECO:0000313|EMBL:KPZ52626.1};
GN Name=hgd {ECO:0000313|EMBL:KPZ52626.1};
GN ORFNames=AN393_03229 {ECO:0000313|EMBL:KPZ52626.1};
OS Pseudoalteromonas sp. P1-25.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=1723758 {ECO:0000313|EMBL:KPZ52626.1, ECO:0000313|Proteomes:UP000050552};
RN [1] {ECO:0000313|EMBL:KPZ52626.1, ECO:0000313|Proteomes:UP000050552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1-25 {ECO:0000313|EMBL:KPZ52626.1,
RC ECO:0000313|Proteomes:UP000050552};
RA Jackson K.R., Lunt B.L., Fisher J.N.B., Gardner A.V., Bailey M.E.,
RA Deus L.M., Earl A.S., Gibby P.D., Hartmann K.A., Liu J.E., Manci A.M.,
RA Nielsen D.A., Solomon M.B., Breakwell D.P., Burnett S.H., Grose J.H.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPZ52626.1}.
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DR EMBL; LKDW01000031; KPZ52626.1; -; Genomic_DNA.
DR RefSeq; WP_055015181.1; NZ_LKDW01000031.1.
DR AlphaFoldDB; A0A0Q0HEK8; -.
DR PATRIC; fig|1723758.3.peg.3290; -.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000050552; Unassembled WGS sequence.
DR GO; GO:0043718; F:2-hydroxymethylglutarate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:KPZ52626.1}.
FT DOMAIN 4..158
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 167..284
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 173
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 293 AA; 31139 MW; 62B79D2FC5B54FC3 CRC64;
MSINVAFIGL GVMGYPMAGH LAKSGFNVCV YNRTTAKAQT WTEQYTGCFA PTPREAVSEA
DIVFMCVGND NDLRSVVYGD DGVLAGMLPH TVLVDHTTTS AEVAREVAAK AALQNIDFID
APVSGGQAGA ENGVLTVMAG GNEAVFTKVQ PVMAAYSRFS QLLGDVGAGQ LCKMVNQICI
AGVVQGLSEG LHFAKQAGLD GEKVIETISK GAAGSWQMEN RYKTMWAGEY EFGFAVDWMR
KDLGIALDEA KNNGATLPMT ATVDQYYADV QALGGGRYDT SSLLARIEAL HKK
//
