ID A0A0Q0VMT7_9SPHI Unreviewed; 803 AA.
AC A0A0Q0VMT7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Tyrosine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AQF98_02210 {ECO:0000313|EMBL:KQC02414.1};
OS Pedobacter sp. Hv1.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=1740090 {ECO:0000313|EMBL:KQC02414.1, ECO:0000313|Proteomes:UP000050543};
RN [1] {ECO:0000313|EMBL:KQC02414.1, ECO:0000313|Proteomes:UP000050543}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hv1 {ECO:0000313|EMBL:KQC02414.1,
RC ECO:0000313|Proteomes:UP000050543};
RA Ott B.M., Beka L., Graf J., Rio R.;
RT "Draft Genome Sequence of a Pedobacter sp. Strain Hv1, an Isolate From
RT Medicinal Leech Mucosal Castings.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQC02414.1}.
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DR EMBL; LLWP01000001; KQC02414.1; -; Genomic_DNA.
DR RefSeq; WP_055130283.1; NZ_LLWP01000001.1.
DR AlphaFoldDB; A0A0Q0VMT7; -.
DR STRING; 1740090.AQF98_02210; -.
DR OrthoDB; 9794577at2; -.
DR Proteomes; UP000050543; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000050543};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..107
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 580..699
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 803 AA; 90283 MW; 66DA8440B78C1525 CRC64;
MSNLETAPSP KSVRQDIDFY KIFKVFFSRW YWIAGCVVIA LIIARINLLY TPPVFTTSGQ
LQLKENNPSI STTQGIATQS YSYTDRIQAE GYVMQSSEVL LNAISNLDYK ISYYNKGRIR
STETYPNKPF TIEIVKQDSV NFGRALYNVE PLNNTTFYLT YTENPKSQKK KYHYGQLIEE
GNTIFKITSP ITGPGQYSFK FNSKMDFLGR SIISTSEAGR FTNVMSVNIT DGNPVFAADF
LNEIMKEYVK YDIVQKRRSA RQMVQFIEKQ MGFLKREADT AGAKLANFKN KNKIVDLNSN
AQTNIAKLGQ FESQKMALDI EMIGINQLEN QVSSNAGKIE MNLDIEGNIS TLLGGLISQY
NTLVLARENK LQQFQASSQL VKDIDEQIGG IRNVIQSNIN SLKQRNLKTL ALLSRQIVDV
NQTLDKIPNK EKDFIQFQSS FDVNNKYLSL LSEKKLESEL NESAVVSGAV IVNQATPPSY
DYPISPDKQK VYTFAAMVGL ACGFGLILLV RFLNPYIYDK ETVEALTNTP IIGVIRKFPE
YIDKDNRQAL SLAKPKSVFA ESVRSVRTNL SFLAANKKSK TICVTSEVSG EGKSFVTVNL
AGTLALIDKK VVLIAADLRR SKLHKVFGSN NKIGLSSYLS GQKTLEEVTM HDEVHNIDFI
PSGPVPPNPS ELLHTESMKK LLEILTPKYD YVLIDTAPVG LVSDAIPLIR QSDVNIFVIR
SGKSQFRAAA IPERLSREYG LSNWAIVLNA FGDDALHSNY YTTDYARGGG NSTYYYSDYS
GYAGSGYYDD PKKWWEFWKK KDK
//
