ID   A0A0Q0XP05_9FLAO        Unreviewed;       560 AA.
AC   A0A0Q0XP05;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Phenylalanine 4-monooxygenase {ECO:0000313|EMBL:KQC32856.1};
GN   ORFNames=AAU57_05655 {ECO:0000313|EMBL:KQC32856.1};
OS   Nonlabens sp. YIK11.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Nonlabens.
OX   NCBI_TaxID=1453349 {ECO:0000313|EMBL:KQC32856.1, ECO:0000313|Proteomes:UP000051409};
RN   [1] {ECO:0000313|EMBL:KQC32856.1, ECO:0000313|Proteomes:UP000051409}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIK11 {ECO:0000313|EMBL:KQC32856.1,
RC   ECO:0000313|Proteomes:UP000051409};
RA   Kwon Y.M., Kim S.-J.;
RT   "Complete genome of flavobacterium.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954,
CC         ECO:0000256|PIRSR:PIRSR601273-2};
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KQC32856.1}.
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DR   EMBL; LBMJ01000001; KQC32856.1; -; Genomic_DNA.
DR   RefSeq; WP_055411993.1; NZ_LBMJ01000001.1.
DR   AlphaFoldDB; A0A0Q0XP05; -.
DR   STRING; 1453349.AAU57_05655; -.
DR   PATRIC; fig|1453349.3.peg.1179; -.
DR   Proteomes; UP000051409; Unassembled WGS sequence.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR   GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR   InterPro; IPR001273; ArAA_hydroxylase.
DR   InterPro; IPR036951; ArAA_hydroxylase_sf.
DR   InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR   InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR   PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR   PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR   Pfam; PF00351; Biopterin_H; 2.
DR   SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR   PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR601273-2};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:KQC32856.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          1..350
FT                   /note="Biopterin-dependent aromatic amino acid hydroxylase
FT                   family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51410"
FT   COILED          183..210
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         134
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         139
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         229
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ   SEQUENCE   560 AA;  63384 MW;  72058435B8852F0E CRC64;
     MKNASEKIVS NPLIDRLPPH LKQFIKPQNY ELYTAQDQAV WRHVMHKNVE YLSQVAHGSY
     LNGLKKTGIS IDEIPSMYGM NRILKDIGWA AVAVDGFIPP AAFMEFQAYK ILVIAADIRQ
     FENIEYTPAP DIIHEAAGHA PIIASPDYAE YLRRFGEVGS KAISSAHDHD VYEAVRELSI
     LKELRSDQEN HELQEKIKNA EARIVELQNK KVAPSEMALI RNLHWWTVEY GLVGTLDNPK
     LYGAGLLSSI GESKSCLDPE VEKRPYTIDA AYQDFDITRK QPHLYVTPDF AQLSEVLEEF
     ANTMAVRKGG YRGLQKLIDS KSLGTIELST GLQVSGVFKR MIKNEDNEVI FFATQGKTAL
     AYRDKELIGH GAATHKNGFL SPIGKLKGIN LAIEDMGPRD LQAYNFYDNE RIEFTFESGI
     RVEGLNVTGM RNIHGKLILI QFTDCTVTYK DEILFAPSDG MLNLAVGKEI VSAFAGPADH
     HSFDLIFHAV PAGRQESDTK TIKPQYSKRE LAIHELYHKL RTYREDDKIN VSVLEKMKLQ
     VMEHYPEQWL LVHEIDELLQ
//