ID A0A0Q0XRR6_9FLAO Unreviewed; 386 AA.
AC A0A0Q0XRR6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=N-acylneuraminate cytidylyltransferase {ECO:0000256|ARBA:ARBA00012491};
DE EC=2.7.7.43 {ECO:0000256|ARBA:ARBA00012491};
GN ORFNames=AAU57_12935 {ECO:0000313|EMBL:KQC34136.1};
OS Nonlabens sp. YIK11.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Nonlabens.
OX NCBI_TaxID=1453349 {ECO:0000313|EMBL:KQC34136.1, ECO:0000313|Proteomes:UP000051409};
RN [1] {ECO:0000313|EMBL:KQC34136.1, ECO:0000313|Proteomes:UP000051409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIK11 {ECO:0000313|EMBL:KQC34136.1,
RC ECO:0000313|Proteomes:UP000051409};
RA Kwon Y.M., Kim S.-J.;
RT "Complete genome of flavobacterium.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate +
CC diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43;
CC Evidence={ECO:0000256|ARBA:ARBA00001862};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate metabolism.
CC {ECO:0000256|ARBA:ARBA00005141}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SIMILARITY: Belongs to the CMP-NeuNAc synthase family.
CC {ECO:0000256|ARBA:ARBA00010726}.
CC -!- SIMILARITY: Belongs to the KdsC family.
CC {ECO:0000256|ARBA:ARBA00005893}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQC34136.1}.
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DR EMBL; LBMJ01000001; KQC34136.1; -; Genomic_DNA.
DR RefSeq; WP_055413303.1; NZ_LBMJ01000001.1.
DR AlphaFoldDB; A0A0Q0XRR6; -.
DR STRING; 1453349.AAU57_12935; -.
DR PATRIC; fig|1453349.3.peg.2713; -.
DR UniPathway; UPA00628; -.
DR Proteomes; UP000051409; Unassembled WGS sequence.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0008781; F:N-acylneuraminate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006054; P:N-acetylneuraminate metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02513; CMP-NeuAc_Synthase; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR010023; KdsC_fam.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR NCBIfam; TIGR01670; KdsC-phosphatas; 1.
DR PANTHER; PTHR21485; HAD SUPERFAMILY MEMBERS CMAS AND KDSC; 1.
DR PANTHER; PTHR21485:SF3; N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF02348; CTP_transf_3; 1.
DR Pfam; PF08282; Hydrolase_3; 1.
DR SFLD; SFLDG01138; C1.6.2:_Deoxy-d-mannose-octulo; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Transferase {ECO:0000313|EMBL:KQC34136.1}.
SQ SEQUENCE 386 AA; 43178 MW; 9AD6D3405328A969 CRC64;
MKSKGFIPLR KNSKGIPGKN KKKLLGRPLF CWVLGEAIAS QLDHIYVFTD DHDIIRFIEK
EYHWTGKVSA IERSAASATD TASTESAILE FMDTHKEPID FFCLLQATSP FTTAADINKC
LQAVTSGDYD SALTVVNSHR FTWNKNGTPK NYDVFNRPRR QDFEGLLIEN GACYVSSDTA
LRESGNRISG NIATIHMPED SLTEIDSLTD WKIVEELLAA RLKKEKKASK ITHLILDVDG
VFTDGCVYYG SDGELIKKFD MRDGMGLEIL RQYHVNVMVM TSEDSAIVAS RMKKLNIADV
FLGVKDKYSL LSRIAHERNL SFSNMAYIGD DVNDLANICA AGWSFTPANA TLTIKNHADV
ILNNDSANGA IREACEFIIK YNMRFL
//
