ID A0A0Q3E1W6_BRADI Unreviewed; 359 AA.
AC A0A0Q3E1W6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BRADI_5g02090v3 {ECO:0000313|EMBL:KQJ81654.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:KQJ81654.1};
RN [1] {ECO:0000313|EMBL:KQJ81654.1, ECO:0000313|EnsemblPlants:KQJ81654}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQJ81654.1,
RC ECO:0000313|EnsemblPlants:KQJ81654};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQJ81654.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQJ81654.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQJ81654}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQJ81654};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CM000884; KQJ81654.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0Q3E1W6; -.
DR STRING; 15368.A0A0Q3E1W6; -.
DR EnsemblPlants; KQJ81654; KQJ81654; BRADI_5g02090v3.
DR Gramene; KQJ81654; KQJ81654; BRADI_5g02090v3.
DR InParanoid; A0A0Q3E1W6; -.
DR OrthoDB; 405021at2759; -.
DR Proteomes; UP000008810; Chromosome 5.
DR ExpressionAtlas; A0A0Q3E1W6; baseline.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030267; F:glyoxylate reductase (NADP+) activity; IBA:GO_Central.
DR GO; GO:0016618; F:hydroxypyruvate reductase activity; IBA:GO_Central.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd12156; HPPR; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR10996:SF283; OS04G0107500 PROTEIN; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..359
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035999469"
FT DOMAIN 81..357
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 153..326
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 359 AA; 37733 MW; D123BE6D6B080581 CRC64;
MPTVCLLLAC LRHSKAATTT DSIPFPLRST ERSDLAAIPM ETTPPPPSHT DERPLVLLAQ
PLFPEFAAAL AGRYRFALAA DADAAAAAEA RVLLVPGLAR VTAELLGSLP ALELVAATSV
GVDHVDLDTC RRRGLAVTNA GAAFAADSAD YAVGLLVAVL RRVAAADAFV RSGRWAADGD
YPLTTKVSGK RVGIVGLGNI GALVARRLAA FGCAISYHSR SPKPAAPYKF FPAVLDLAAD
SDVLVLSCAL TEETRHMVNR EVMEALGKDG VLVNVGRGGL VDEPELVRCL REGVIGGAGL
DVYENEPAVP RELFAMDNVV LSDHRAVITP ESMRGALEIL VANLDAFFSG RPLVSPVQL
//
