ID A0A0Q3LVE3_AMAAE Unreviewed; 465 AA.
AC A0A0Q3LVE3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 13-SEP-2023, entry version 24.
DE RecName: Full=GDNF family receptor alpha {ECO:0000256|PIRNR:PIRNR038071};
GN ORFNames=AAES_155435 {ECO:0000313|EMBL:KQK74504.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK74504.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK74504.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK74504.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for neurturin. Mediates the NRTN-induced
CC autophosphorylation and activation of the RET receptor. Also able to
CC mediate GDNF signaling through the RET tyrosine kinase receptor.
CC {ECO:0000256|ARBA:ARBA00025392}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961, ECO:0000256|PIRNR:PIRNR038071}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK74504.1}.
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DR EMBL; LMAW01003037; KQK74504.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3LVE3; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR InterPro; IPR003504; GDNF_rcpt_a2.
DR InterPro; IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
DR InterPro; IPR003582; ShKT_dom.
DR PANTHER; PTHR10269:SF4; GDNF FAMILY RECEPTOR ALPHA-2; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 3.
DR PIRSF; PIRSF038071; GDNF_family_receptor_alpha; 1.
DR PRINTS; PR01318; GDNFRALPHA2.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 3.
DR SUPFAM; SSF110035; GDNF receptor-like; 1.
DR PROSITE; PS51670; SHKT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR038071};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038071};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR038071};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|PIRNR:PIRNR038071}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|PIRNR:PIRNR038071"
FT CHAIN 22..465
FT /note="GDNF family receptor alpha"
FT /evidence="ECO:0000256|PIRNR:PIRNR038071"
FT /id="PRO_5011836032"
FT DOMAIN 239..283
FT /note="ShKT"
FT /evidence="ECO:0000259|PROSITE:PS51670"
FT REGION 364..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 465 AA; 51978 MW; 890D8BE6E58ABFC7 CRC64;
MILANAFCIV LFVDELLRSL ASPPSPPGQD PHGWRVPVDC VRANELCAAE ASCSSRYRTL
RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE
EFYEASPYEP VTSRLSDIFR LASIFSGMDP AANSKSNHCL DAAKACNLND NCKRLRSGYI
STCSREISAS EHCSRRKCHK ALRQFFDRVP SEYTYRLLFC SCKDQACAER RRQTIVPSCS
YEDKEKPNCL DLRSTCRTDH LCRSRLADFH TNCQASFQTL TSCPGDNYQA CLGSYAGLIG
FDMTPNYIDA STTSITISPW CSCKGSGNME EECEKFLRDF TENPCLRNAI QAFGNGTDVN
LSPKNPSLPI TLPPKXEKSP ALPDDINDSN TMYDTSIITT CTSVQEXGLK LNKSKEQSLC
YSETQLTTDI MPDQKTFVDQ KAGGSRHWAG RILPTVPILL LLLVL
//
