ID A0A0Q3M326_AMAAE Unreviewed; 549 AA.
AC A0A0Q3M326;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Polycystic kidney disease 2-like 2 protein {ECO:0000313|EMBL:KQK77103.1};
GN ORFNames=AAES_151337 {ECO:0000313|EMBL:KQK77103.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK77103.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK77103.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK77103.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK77103.1}.
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DR EMBL; LMAW01002789; KQK77103.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3M326; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF47; POLYCYSTIC KIDNEY DISEASE 2-LIKE 2 PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 83..277
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 278..502
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT DISULFID 146..159
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 549 AA; 64082 MW; 4617779ED745140E CRC64;
MEPAAAVQLP VVGHRLTGRG APKARESSMS EQELKDMLRE LVIYLIFLID LCILAFGMVS
VDMYHLNTVM SRLFMEPAEG KDGFGTIRSK ADFWKFVQGP LLDGLYWDKW YNXTTLPFXN
YSHIYYENLL LGVVQVRQVK VRNNTCSIYP YFRSFLDDCY SDYHYQAEDR SDDAXRNESE
WKYTPADPFT PWYLGNMGLY SSGGYLFTLP KSKQESMEKL ASLKQNNWLT RGTRAVFIDF
STYNANLNLF CIVRLVVEFP ATGGAFTSIH IYSVKLLRYI TXYDYFLASC EIIFCLFIIT
FIIQEAIKIV KLKXEYFRSG WSWLDLMLLM VSILAIIFNI YSTVEVSLLM EELLSDANVY
PDFYFLTFWQ VLYNNMIAVN IFFAWIKVLK YVRFNRTMEQ LSSTLSRCAK DIIGFAVMFF
IVFFAYAQFG YLVFGSQVEE FSTFQKCVFT QFRLVLGEFE FENTEAVNRI LGPIYFISFV
FFVFFXLLNM FLAIINDTYS EVKADYDMMP SHKVPIRDLF RHSCDNALTK LKLKKPEEDT
QPAAEKLER
//
