ID A0A0Q3P9W6_AMAAE Unreviewed; 235 AA.
AC A0A0Q3P9W6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Interleukin-6 {ECO:0000256|ARBA:ARBA00019464};
GN ORFNames=AAES_32696 {ECO:0000313|EMBL:KQL03145.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQL03145.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQL03145.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQL03145.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the IL-6 superfamily.
CC {ECO:0000256|ARBA:ARBA00007432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQL03145.1}.
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DR EMBL; LMAW01000583; KQL03145.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0Q3P9W6; -.
DR STRING; 12930.A0A0Q3P9W6; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR GO; GO:0005138; F:interleukin-6 receptor binding; IEA:InterPro.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR GO; GO:0072540; P:T-helper 17 cell lineage commitment; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR003574; IL-6-like.
DR InterPro; IPR030474; IL-6/GCSF/MGF.
DR InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR PANTHER; PTHR48406; INTERLEUKIN-6; 1.
DR PANTHER; PTHR48406:SF1; INTERLEUKIN-6; 1.
DR Pfam; PF00489; IL6; 1.
DR PRINTS; PR00433; IL6GCSFMGF.
DR PRINTS; PR00434; INTERLEUKIN6.
DR SMART; SM00126; IL6; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00254; INTERLEUKIN_6; 1.
PE 3: Inferred from homology;
KW Acute phase {ECO:0000256|ARBA:ARBA00022486};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..41
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 42..235
FT /note="Interleukin-6"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006206327"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 235 AA; 26744 MW; 12A33BEBEF66D4A1 CRC64;
MRLPQGCDCD HDRNRAARRR QPSLRSVLPL LLLLLLPRAA AAPLPAADSS GEAELEEAAG
RQAALPDCER LARLLHARAA QLQEEMCEKF TVCENSMEML IQNNLNLPKV MEEDGCLLTG
FNEDKCLRKI SSGLYTFQTY LQFIQETFTS EKQNIESLCY TTEHLAHTVK QMVINPDEII
IPDSATQESL RAKLKSDKTW IEKITTHLIL RDFTSFMEKT VRAVRYLKNT RSFSV
//
