ID A0A0Q3PK06_AMAAE Unreviewed; 901 AA.
AC A0A0Q3PK06;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000259|PROSITE:PS50262};
GN ORFNames=AAES_137061 {ECO:0000313|EMBL:KQK76508.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK76508.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK76508.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK76508.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide)
CC neuropeptides, also known as morphine-modulating peptides. Can also be
CC activated by a variety of naturally occurring or synthetic FMRF-amide
CC like ligands. This receptor mediates its action by association with G
CC proteins that activate a phosphatidylinositol-calcium second messenger
CC system. {ECO:0000256|ARBA:ARBA00025478}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK76508.1}.
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DR EMBL; LMAW01002845; KQK76508.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3PK06; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0008188; F:neuropeptide receptor activity; IEA:InterPro.
DR GO; GO:0031628; F:opioid receptor binding; IEA:InterPro.
DR GO; GO:0043408; P:regulation of MAPK cascade; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR InterPro; IPR005395; NPFF_rcpt.
DR InterPro; IPR005397; NPFF_rcpt_2.
DR PANTHER; PTHR24241:SF132; NEUROPEPTIDE FF RECEPTOR 2; 1.
DR PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 2.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01570; NPFFRECEPTOR.
DR PRINTS; PR01572; NPFFRECEPTR2.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SMART; SM00328; BPI1; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..901
FT /note="G-protein coupled receptors family 1 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006206466"
FT TRANSMEM 521..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 540..811
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 901 AA; 101008 MW; FBFCFB29265F40AE CRC64;
MLKAWYSFLL CWLSLQLEAN PGLKVRITQK GLDYGRRIGL ELLKQEVLKE TFPSWSGQES
FSIVKVNYVI SRLRINAIDF PESSASFIPG TGISLSVAHA SATISADWKM NAWLLKDQGG
ITVSISGLFI AVIIKVSRDS TGRLSMLLHD CQTSINXVKV KLSAGSSWIY SFLSGYIEKP
VHTKLNKNLC LNIKYKIQMM DAHLRNXKDV LVLSILLVLN QIDAFVQIDY SLVSSPAVFK
SHMNLDLKGT VYPVGNHTDP PFVPAPFALP NKDDSMLYLG VSSYFLKSAS LAYYKAGAFN
ITMSKEIALS YLTACPMLLK LMATSPPVVS LNADRCILHI TGXVEVFAVL PYSTTQYIFA
GNLTASTRVY LTITKQKLII SLLLKRLQFS LLHSILGFSE QMSLAENFLS YALRSAVIPV
INVLHVAPSF IADRMQCTWK EQSKGDMDDS RTAYVWIEHH LYVDSLNPTG YITVCTLYTS
KKMDSNSPFE WPHTLNYNGT YKHLYLERNV SYVDFYLHQP LVAAVFTISY LLIFLLCMAG
NGVVCFIVLR SKRMRTVTNL FILNLAVSDL LVGIFCMPTT LLDNIIAGWP FGSLICKMSG
MVQGISVSAS IFTLVAIAVD RFRRIVDPFK QKLTSATAVA SIVLIWILAV AIMCPSVVML
QVQEDKHFRV ILGYGNETXP VYWCREDWPD PGMRKIYTTV LFASIYLAPL SLLVLMYARI
CIALCNTAVP VGGKDSQEQR HSRSKKKQKV IKMLIIVALL FALSWLPLWT LMMLTDYANL
SDMQLQIINI YIYPFAHWLA FFNSSVNPII XGFFNENFRR GFQAASKLQL CSRXVXHGEL
XSQQDQGNAI LPAANDQMPQ DQACQNAEEE VGKTVKKGNW VNNQQDLVME DLEEPCSDGL
K
//
