ID A0A0Q3PLG1_AMAAE Unreviewed; 781 AA.
AC A0A0Q3PLG1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 22-FEB-2023, entry version 24.
DE SubName: Full=Axin-2 {ECO:0000313|EMBL:KQK81827.1};
GN ORFNames=AAES_77500 {ECO:0000313|EMBL:KQK81827.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK81827.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK81827.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK81827.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK81827.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LMAW01002169; KQK81827.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3PLG1; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd11582; Axin_TNKS_binding; 1.
DR CDD; cd08707; RGS_Axin; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.40.240.130; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR043581; Axin-like.
DR InterPro; IPR014936; Axin_b-cat-bd.
DR InterPro; IPR032101; Axin_TNKS-bd.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46102; AXIN; 1.
DR PANTHER; PTHR46102:SF1; AXIN-2; 1.
DR Pfam; PF16646; AXIN1_TNKS_BD; 1.
DR Pfam; PF08833; Axin_b-cat_bind; 1.
DR Pfam; PF00778; DIX; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00021; DAX; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW ProRule:PRU00069}.
FT DOMAIN 84..203
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 699..781
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 781 AA; 87035 MW; C1567EDE55DF162B CRC64;
MSSAXLLAHL PDPSTSFRED APRPPVPGEE GEAPCPHLAS SFLPKSQSFK AMPVPPAPRR
NENGLGEPEG SASPDSPLAR WTKSLHSLLG DQDGAYLFRT FLEREKCVDT LDFWFACNGF
RQMDLKDTKT LRVAKAIYKR YIENNSIVSK QLKPATKTYI RDSIKKQQID SIMFDQAQTE
IQTVMEENAY QMFLTSDIYL EYVRSGGENP AYMNSNGLGS LKVVCGYLPT LNEEEEWSCA
DFKHKILPSV VGLSSKTLRV TANVRATETI ENGYRCFKRN DPVNPYHVNS GYVFAPATSA
NDSEISSDAL TDDSMSMTDS SVDGIPPYRI GSKKQLQREM HRSVKANGQV SLPHFPRTHR
LPKEMTPVEP AAFAAELISR LEKLKQEQEA MDSLEERLQQ IKEDEEKEGS ELPGSLQSSR
EMXNPQHPLS LLPSSSYEED PQAILDEHLS RVLKTPGCQS PGMARHSPRA RSPDRLPMGK
LPPGAASLAA CTLLGKGFIT KQTTKHVHHH YIHHHTVPKT KEQIEAEAAQ RVQCCCPAGS
DFYCYPKCKG HPKNTDPPLP PLEPFGRTGT LLKRPGRGAD SIALPPGDGG LPGPGGVQLP
GGEADRAQNV WQWMLESERQ NKHKPHSTQS TKKAYSSDCA KGAPGRHHPW GTSSHPRGAQ
PAHPFVQDPA MPPLTPPNTL AQLEEACRRL AEVSKPQKQR ELVVTYFFCG EEIPYRRMLK
AQSLTLGLFK EQLSKKGNYR YYFKKASDEF DCGAVFEEIW EDETILPMYE GRILGKVERI
D
//
