ID A0A0Q3PR11_AMAAE Unreviewed; 1211 AA.
AC A0A0Q3PR11;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
GN ORFNames=AAES_115076 {ECO:0000313|EMBL:KQK78452.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK78452.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK78452.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK78452.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK78452.1}.
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DR EMBL; LMAW01002665; KQK78452.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3PR11; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10375; SH2_STAT4; 1.
DR CDD; cd16851; STAT1_CCD; 1.
DR CDD; cd16845; STAT1_DBD; 1.
DR CDD; cd16854; STAT4_CCD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 2.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 2.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR046991; STAT4_CCD.
DR InterPro; IPR035856; STAT4_SH2.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF18; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA_BETA; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 2.
DR Pfam; PF02864; STAT_bind; 2.
DR Pfam; PF02865; STAT_int; 2.
DR Pfam; PF21354; STAT_linker; 2.
DR SMART; SM00964; STAT_int; 2.
DR SUPFAM; SSF49417; p53-like transcription factors; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 2.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 2.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 490..592
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 1211 AA; 139994 MW; 53008BD00B07B2C2 CRC64;
MSQWSQVQQL EIKFLEQVDQ FYDDNFPMEI RHLLAQWIES QDWEAASNNE AMATILLQNL
LIQVDEQLDR VSQEKNLLLI HNLKRIRKLL QGKYHGNPMH IAVIISNCLR EERRILAAAS
MPVQMTDQDV KYLEDLQEEF DFRYKTIQSL EQSDKNSALI KQEMLALQAM LNTLDYKRKE
VLSKIGRVIH EIDMLMSNML TEELLDWKRR QQIACIGGPL HGGLDQLQNC FTLLAESLFQ
VRRQLEKLDE LLTRLTYDGD PIPVQRPQLL EKVNFLLYNL FRKLLIKLPE LNYQIRVKAT
IDKNVSTVRF ILCGTHMKAM NMDESANGSL SVEFRHLGPH MVTEELHSIS FETQVCLYGL
TINLETSSLP VVMISNVSQL PNAWASIIWY NLSTNDPQNL SFFNNPPAAT LSQLLEVLSW
QFSSYVGRGL NSEQLNMLAE KLTGQQVSYN DYXLSWAKFC KEHLPGKSFT FWVWLEAILD
LIKKHILPLW IDGYIMGFVS KEKERILLKD KTPGTFLLRF SESNLGGITF TWVDQLENGD
VTFHSVEPYN KGRLSALPFA DILRDYKVIM ADNVPENPLK YLYPDIPKDK AFGKHYSCQP
NEVSKPSDGG GKGYVPSVFI PVSKMMAQWY QLQQLDSKFL EQVHQLYDDS FPMEIRQYLA
QWLENQDWEH AANNVSFATV LFHDLLSQLD DQFSRFLIEN NFLLQHNIRK SKRNLQDNFQ
EDPIQMAMII CSCLKEERKI LSSARLSNQM EVGSIQNTVI GMLDKQKELD AEVKGVKNHV
IDVEQDIKTL EDMQDEYDFK CKTLQNREHE SNSTSQEEYK KEQMHLNKMF LSLDLKRKEV
VNKIVQLLNA TEHTQTALIN EELVEWKRRQ QTACIGGPPN ACLDQLQNWF TIVAESLQQV
RQQLKKLEEL EQKFTYDPDP ITKNKQVLQD RTHSLFKQLI QSSFVVERQP CMPTHPQRPL
VLKTGVQFTV KLRLLVKLQE LNYNLKVKVL FDKDVSEKNS VKGXVASVWF RKFNILGTST
KVMNMEESTN GSLAAEFRHL QLKEQKNAGS RTNEGPLIVT EELHSLSFET QLCQPGLVID
LETTSLPIVV ISNVSQLPSG WASILWFNML STDPKNLSFF LNPPYAKWSK LSEVLSWQFS
SVTKRGLNAD QLSMLGEXLL GPTSGGSHDC LIPWTRFCKE NINDKNFPFW LWIEGILELI
KKHLLCLWNX G
//
